Evidence map›Paper›PMID 40904945›Full record

ArticlePure and applied chemistry. Chimie pure et appliquee2019

Synthesis of a novel brominated vinylic fatty acid with antileishmanial activity that effectively inhibits the

Néstor M Carballeira, Denisse Alequín, Leilani M Lotti Diaz, Victorio Jauregui Matos, Leonardo L G Ferreira, Adriano D Andricopulo, Mikhail Y Golovko, Rosa M Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce

Abstract read
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In one paragraph

Article in Pure and applied chemistry. Chimie pure et appliquee, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Néstor M CarballeiraUniversity of Puerto Rico, Río Piedras Campus, 17 Ave Universidad STE 1701, San Juan, PR 00925-2537, USA, Tel.: (787)-764-0000 ext, 88561.
Denisse AlequínDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, PR, USA.
Leilani M Lotti DiazDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, PR, USA.
Victorio Jauregui MatosDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, PR, USA.
Leonardo L G FerreiraLaboratory of Medicinal and Computational Chemistry, Center for Research and Innovation in Biodiversity and Drug Discovery, Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, SP 13563-120, Brazil.
Adriano D AndricopuloLaboratory of Medicinal and Computational Chemistry, Center for Research and Innovation in Biodiversity and Drug Discovery, Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, SP 13563-120, Brazil.
Mikhail Y GolovkoDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 N Columbia Road, Grand Forks, ND 58202-9037, USA.
Rosa M RegueraDepartment of Biomedical Sciences, University of León, Campus de Vegazana, León 24071, Spain.
Yolanda Pérez-PertejoDepartment of Biomedical Sciences, University of León, Campus de Vegazana, León 24071, Spain.
Rafael Balaña-FouceDepartment of Biomedical Sciences, University of León, Campus de Vegazana, León 24071, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many marine derived fatty acids, mainly from sponges, possess vinylic halogenated moieties (bromine or iodine) but their assessment as antileishmanial candidates remains elusive. In this work, we undertook the first total synthesis of a novel series of 2-allyl-3-halo-2-nonadecenoic acids, which preferentially inhibit the

Indexed as

brominated fatty acidshalogen bondLeishmania infantumleishmaniasisNTD2018synthesistopoisomerase IB

Identifiers

PMID40904945
PMCPMC12403660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.