Evidence map›Paper›PMID 40904902›Full record

ArticleInfection and drug resistance2025

Epidemiology, Risk Factors, and External Validation of Predictive Models for Multidrug-Resistant Bacterial Infections in Diabetic Foot Ulcers.

Xiangheng Dai, Fuzhou Xu, Weiqi Lu, Guiping Zhang, Yuyue Li, Xinying Hu, Lijing Deng, Kun Zhao, Wenlian Zheng, Beidi Zhou and 2 more

Abstract read
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Moderate discrimination but attenuated predictive precision: a multi-model external validation of prolonged postoperative length of stay models after lumbar interbody fusion in an independent cohort.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiangheng Dai *Department of Spinal Surgery, Shaoguan First People's Hospital, Guangdong Medical University, Shaoguan, People's Republic of China.ORCID 0000-0003-4324-3507
Fuzhou Xu *The First Clinical College of Guangdong Medical University, Zhanjiang, People's Republic of China.ORCID 0009-0009-7507-9861
Weiqi LuThe First Clinical College of Guangdong Medical University, Zhanjiang, People's Republic of China.
Guiping ZhangSchool of Medicine, Shaoguan University, Shaoguan, People's Republic of China.ORCID 0009-0007-6657-2457
Yuyue LiSchool of Medicine, Shaoguan University, Shaoguan, People's Republic of China.ORCID 0009-0008-0059-110X
Xinying HuSchool of Medicine, Shaoguan University, Shaoguan, People's Republic of China.ORCID 0009-0000-1239-2345
Lijing DengSchool of Medicine, Shaoguan University, Shaoguan, People's Republic of China.
Kun ZhaoThe First Clinical College of Guangdong Medical University, Zhanjiang, People's Republic of China.
Wenlian ZhengDepartment of Burn and Wound Repair, Shaoguan First People's Hospital, Guangdong Medical University, Shaoguan, People's Republic of China.ORCID 0009-0000-3152-1253
Beidi ZhouDepartment of Prevention and Health Care, Shaoguan First People's Hospital, Guangdong Medical University, Shaoguan, People's Republic of China.
Guobao DengDepartment of Endocrinology, Shaoguan First People's Hospital, Guangdong Medical University, Shaoguan, People's Republic of China.ORCID 0009-0003-0344-3579
Qiang WuDepartment of Spinal Surgery, Shaoguan First People's Hospital, Guangdong Medical University, Shaoguan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate the epidemiological characteristics and risk factors of multidrug-resistant bacterial (MDRB) infections in diabetic foot ulcer (DFU) and externally validate existing predictive models for MDRB, Methods: A retrospective analysis of 344 patients diagnosed with DFU identified key clinical and laboratory variables associated with outcomes. Univariate and multivariate logistic regression identified risk factors, while receiver operating characteristic (ROC) curves and calibration analyses assessed model validity. Results: MDRB infections were linked to longer hospitalization, lower hemoglobin, higher hs-CRP, and higher osteoporosis prevalence. Significant risk factors included prolonged hospitalization, osteomyelitis, osteoporosis, prior antimicrobial use, and respiratory rate. Conclusion: MDRB infections in DFUs are associated with specific clinical characteristics and risk factors. However, existing predictive models demonstrated limited utility in our dataset, emphasizing the need for model refinement and inclusion of additional risk factors. Future research should focus on improving predictive models and developing targeted antimicrobial strategies to enhance clinical outcomes in diabetic foot infections.

Indexed as

diabetic foot ulcersmodel validationmultidrug-resistant bacteriapredictive modelsrisk factors

Identifiers

PMID40904902
PMCPMC12402424

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.