Observational studyWorld journal of gastroenterology2025
Serum metabolomic characteristics and their predictive value for ninety-day prognosis in patients with acute-on-chronic liver failure.
Observational study in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute-on-chronic liver failure (ACLF) is characterized by severe metabolic disturbances; however, the specific metabolomic features and their predictive value on 90-day prognosis remain unclear.
aimTo identify serum metabolomic changes in patients with ACLF with different prognoses to support clinical prediction of outcomes and treatment decisions.
methodsThis non-interventional, observational case-control study enrolled 58 patients with ACLF. Fasting venous blood samples were analyzed using targeted metabolomics. Univariate and multivariate statistical analyses identified differential metabolites among 18 amino acids, 11 fatty acids, 5 gut microbiota-related metabolites, and 4 bile acid metabolites. Binary logistic regression identified independent mortality risk factors, visualized
resultsSignificant differences (
conclusionThe age-NLR-Arg model demonstrates a strong predictive value for 90-day mortality risk in patients with ACLF.
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