Evidence map›Paper›PMID 40904716›Full record

ArticleInternational journal of sports physical therapy2025

Hamstrings Volumetric Adaptations to a Four-Week Nordic Hamstring Exercise Protocol in Individuals with ACL Reconstruction: A Preliminary Case Series.

Grant E Norte, Amanda M Murray, Justin L Rush, David A Sherman, Neal R Glaviano

Registry-linked trialAbstract read
In one paragraph

Article in International journal of sports physical therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07384780 (Isokinetic Exercise Combined With Blood Flow Restriction), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07384780 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training : A Randomized Controlled Trial in Post-ACL Reconstruction Populations

TypeinterventionalSponsorGulf Medical UniversityRan2026 to 2026Enrolled60ConditionsACL Reconstruction, ACL RepairArmsHigh Load Isokinetic Training with Blood Flow Restriction, Low Load Isokinetic Training with Blood Flow Restriction
3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Grant E NorteKinesiology University of Central Florida.ORCID https://orcid.org/0000-0001-8052-3642
Amanda M MurrayExercise and Rehabilitation Sciences University of Toledo.
Justin L RushPhysical Therapy Ohio University.
David A ShermanPhysical Therapy, Human Movement, and Rehabilitation Sciences Northeastern University.
Neal R GlavianoKinesiology University of Connecticut.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hamstrings atrophy is widely reported following anterior cruciate ligament reconstruction (ACLR) with hamstrings tendon (HT) autograft. Nordic hamstring exercise (NHE) has yielded improvements in hamstrings volumes among uninjured individuals, yet this has not been investigated following ACLR. Purpose: To describe changes in hamstrings volumes following an isolated NHE protocol among individuals with a history of ACLR via HT. Study Design: Prospective case series. Methods: Individuals (age 18-35) with primary, unilateral ACLR via HT was recruited from an a larger clinical trial. Participants were not engaged in formal rehabilitation at enrollment. Outcomes were assessed in a university research laboratory and medical center. Involved limb muscle volumes were quantified for the total hamstrings, biceps femoris long head, biceps femoris short head, semimembranosus, and semitendinosus via magnetic resonance imaging before and after a standardized, progressive four-week (10-session) NHE protocol. Average peak eccentric force was quantified using a NordBord dynamometer during the first and last exercise sessions. Change scores were reported descriptively as percentages (%) and their magnitudes were quantified using effect sizes (Cohen's d). Results: Seven individuals participated (age: 22.0±2.3 years, time from surgery: 53.6±29.5 months). Volumetric changes ranged -6.0 to 17.6% across participants and muscles. On average, trivial-to-moderate magnitude increases in hamstrings volumes (3.3-7.2%, d=0.12-0.53) were observed, except for semimembranosus (0.0%, d=0.01). Changes in eccentric force ranged -3.2 to 19.4% across participants. On average, a moderate magnitude increase in force (11.0%, d=0.53) was observed. Conclusion: The majority of participants in this case series demonstrated trivial-to-moderate increases in hamstrings muscle volumes in parallel with a moderate increase in eccentric force after four weeks of isolated NHE. Variable responses to exercise appear to support the need for individualized exercise prescription in this population. Level of Evidence: 4.

Indexed as

atrophyeccentricknee flexorsstrength

Identifiers

PMID40904716
PMCPMC12404571

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.