Evidence map›Paper›PMID 40904703›Full record

ArticleMedComm2025

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic

Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai-Ning Chen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Tao ZhouDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China.
Huayun YanState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Dandan YinState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Yun DengState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Huancheng FuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Zichen ZhaoDepartment of Medical Oncology Lung Cancer Center/Lung Cancer Institute West China Hospital Sichuan University Chengdu Sichuan China.
Shuang LiDepartment of Pathology West China Hospital Sichuan University Chengdu Sichuan China.
Xiaoxi LuDepartment of Pediatric Hematology/Oncology West China Second Hospital Sichuan University Chengdu Sichuan China.
Yiqi DengState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Hai-Ning ChenDepartment of General Surgery Colorectal Cancer Center West China Hospital Sichuan University Chengdu Sichuan China.
Wei-Han ZhangInstitute of General Surgery West China Hospital Sichuan University Chengdu Sichuan China.
Yunying ShiDepartment of Nephrology West China Hospital Sichuan University Chengdu Sichuan China.
Yangjuan BaiDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China.
Bei CaiDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China.
Lanlan WangDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China.
Zhaoqian LiuDepartment of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Xiangya Hospital Central South University Changsha Hunan China.
Wei ZhangDepartment of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Xiangya Hospital Central South University Changsha Hunan China.
Lili JiangDepartment of Pathology West China Hospital Sichuan University Chengdu Sichuan China.
Yang ShuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Bo LiuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu China.
Yan ZhangDepartment of Medical Oncology Lung Cancer Center/Lung Cancer Institute West China Hospital Sichuan University Chengdu Sichuan China.
Heng XuDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic retinoblastoma 1 (

Indexed as

collateral lethalitycopy number deletiondrug repurposingmercaptopurineNUDT15RB1

Identifiers

PMID40904703
PMCPMC12402595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.