ArticleFrontiers in microbiology2025
Beyond clinical data: the role of sewage monitoring in tracking pandemic trends of SARS-CoV-2.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The SARS-CoV-2 pandemic has caused a global crisis that has impacted not only health care systems, but also economies and societies. The constraints in clinical testing provide challenges in reliably assessing the prevalence of variations, particularly in regions with limited resources, testing, and sequencing capabilities. Sewage-based epidemiology uses SARS-CoV-2 in sewage as an indicator, can monitor and provide early warning of viral transmission in communities, thereby informing response strategies. Methods: In this study, sewage samples and clinical patient samples were collected in Yantai City, Shandong Province. RT-qPCR and high-throughput sequencing techniques were employed to identify and analyze SARS-CoV-2, respectively. Results: Our results showed that the dynamic trend of SARS-CoV-2 RNA concentration in sewage samples coincided with the positive rate of clinical surveillance cases (Spearman's Discussion: Our study demonstrates that effluent genomic surveillance is a rapid, sensitive, and scalable method. It enables the timely identification of SARS-CoV-2 variants and the detection of hidden transmission. It can be applied to SARS-CoV-2 early warning as well as epidemiologic surveillance. However, this study has certain limitations. First, due to financial constraints, only a limited number of clinical samples were analyzed, which may have underestimated the diversity of SARS-CoV-2 lineages in the patient population. Second, the absence of information on the physicochemical characteristics of sewage may have limited our understanding of environmental factors affecting viral stability and detection efficiency.
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