ArticleFrontiers in psychiatry2025
Active inference and psychodynamics: a novel integration with applications to depression and stress disorders.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Embodied Neuropsychodynamics of the Relational Self Across Space and Time: An Integrative Narrative Review.Brain sciences · 2026Review
- Active Inference and Functional Parametrisation: Differential Flatness and Smooth Random Realisation.Entropy (Basel, Switzerland) · 2026Article
- From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.Frontiers in cell and developmental biology · 2026Review
- Autonomic regulation constrains psychotherapeutic workability: a state-dependent translational model for psychotherapy and psychosomatics.Frontiers in psychiatry · 2026Article
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Authors and funding
1 author.
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Abstract
This paper introduces Active Intersubjective Inference (AISI), a novel framework that integrates psychodynamic theory with predictive processing to explain self-identity construction and psychopathology. AISI posits that the self emerges from recursive inferences about how others perceive us (second-order self), interacting bidirectionally with interoceptive processes. We map psychodynamic phenomena (e.g., transference, projection) onto neurocomputational mechanisms and apply AISI to Major Depressive Disorder (MDD) and Post-Traumatic Stress Disorder (PTSD), highlighting distorted second-order inference as a core dysfunction. Therapeutic implications include psychodynamic therapy, cognitive-behavioral approaches, and psychedelic-assisted treatments to enhance inference flexibility. AISI bridges psychodynamic insights with the NIMH Research Domain Criteria, offering a testable model for precision psychiatry and future clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.