Trial reportDrug design, development and therapy2025
Effects of Dexmedetomidine on Postoperative Quality of Recovery and Electroencephalogram in Elderly Patients Undergoing Total Knee Arthroplasty: A Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of spontaneous breathing anesthesia on postoperative cognitive dysfunction in elderly patients: a narrative review.Frontiers in surgery · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Anesthesia management strategies in elderly patients undergoing total knee arthroplasty (TKA) are critical to the postoperative quality of recovery (QoR), and changes in electroencephalogram (EEG) associated with anesthesia drugs may play an important role in this process. This study aimed to determine the effects of different doses of dexmedetomidine on postoperative QoR in elderly TKA patients, and whether there is a correlation with specific EEG changes. Methods: In this randomized controlled trial, elderly patients (aged ≥ 60 years) undergoing elective TKA were randomly allocated in a 1:1:1 ratio to 0.6 μg/kg/h dexmedetomidine (Group D2), 0.3 μg/kg/h dexmedetomidine (Group D1) and saline (Group N). On postoperative days 1 and 3, the15-item Quality of Recovery (QoR-15) scale was used to evaluate the postoperative recovery of patients among the three groups. Perioperative EEG data were also recorded. Results: The difference of QoR-15 scores on postoperative day 1 was significant for Group D2 vs Group N (126 [123-129] points vs 120 [116-123] points; median difference, 6 points [95% CI, 4 to 8]; Conclusion: A loading dose of dexmedetomidine (0.5 μg/kg) infused within 10 minutes before anesthesia induction, followed by a maintenance at 0.6 μg/kg/h, improved QoR-15 on postoperative day 1 in elderly TKA patients, which may be partly related to the fact that dexmedetomidine deepens anesthesia by increasing the slow oscillation peak power in the appropriate range.
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