Evidence map›Paper›PMID 40904545›Full record

Trial reportDrug design, development and therapy2025

Effect of Stellate Ganglion Block on Preventing Atrial Fibrillation After Esophagectomy: A Double-Blind Randomized Controlled Trial.

Tieshuai Liu, Jun Zhang, Jingwen Liang, Raojun Luo, Ziming Zhang, Jiwen Li, Zhichao Ai, Jiaqi Xiong, Shameera Sayer, Qihong Shen and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tieshuai Liu *Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Jun Zhang *Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.ORCID 0009-0003-7597-3376
Jingwen Liang *Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Raojun LuoDepartment of Thoracic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Ziming ZhangNeonatal Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Jiwen LiDepartment of Cardiac Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.ORCID 0000-0002-8595-860X
Zhichao AiDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.ORCID 0009-0003-8021-3232
Jiaqi XiongDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Shameera SayerInternational School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.ORCID 0009-0004-8148-3581
Qihong ShenDepartment of Anesthesiology, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of China.ORCID 0000-0003-3365-779X
Xin YuDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.ORCID 0000-0002-6967-8704
Gang ChenDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.ORCID 0000-0003-4262-9491

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative atrial fibrillation (POAF) is a common complication after esophagectomy and is associated with adverse outcomes. This study investigated whether preoperative stellate ganglion block (SGB) could reduce the incidence of POAF and improve postoperative recovery. Methods: In this single-center, randomized, double-blind, placebo-controlled trial, 100 patients undergoing esophagectomy were randomly assigned to receive ultrasound-guided right-sided SGB with 7 mL of either 0.5% ropivacaine (SGB group) or normal saline (control group). The primary outcome was the incidence of POAF within 72 hours postoperatively. Secondary outcomes included the timing and duration of POAF, heart rate variability, other arrhythmias, sufentanil consumption, pain scores, vital signs, sleep quality, gastrointestinal recovery, length of hospital stay, complications and mortality. Results: The incidence of POAF was 10% in both groups (OR = 1.0, 95% CI: 0.27-3.69, Conclusion: Although SGB did not reduce the incidence of POAF, it was associated with improved postoperative recovery. These findings suggest that SGB may serve as a beneficial adjunct to optimize recovery following esophagectomy.

Indexed as

Atrial FibrillationEsophagectomyPostoperative ComplicationsRopivacaineStellate GanglionAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedRopivacaineautonomic nervous systemesophagectomypostoperative atrial fibrillationsleep qualitystellate ganglion block

Identifiers

PMID40904545
PMCPMC12404266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.