Evidence map›Paper›PMID 40904473›Full record

ArticleOpen forum infectious diseases2025

Sleep and Rest-Activity Rhythms are Delayed and Less Robust in People Living With HIV.

Priya V Borker, Stephen F Smagula, Julia Sherman, Alison Morris, Bernard Macatangay, Sanjay R Patel

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priya V BorkerDivision of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-3957-7363
Stephen F SmagulaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Julia ShermanDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alison MorrisDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bernard MacatangayDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Sanjay R PatelDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Impact of Poor Sleep on Inflammation and the Adenosine Signaling Pathway in HIV InfectionR01HL142118 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MACATANGAY, BERNARD JONAS C, PATEL, SANJAY R · 2018 to 2021
$2.1M
Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)K12HL143886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MELLORS, JOHN W, MORRIS, ALISON · 2018 to 2022
$1.7M
Understanding the association of sleep on monocyte action in HIV infectionK23HL169022 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Priya Vassant Borker · 2024 to 2026
$631k
NHLBI NIH HHS K12 HL143886NHLBI NIH HHS K23 HL169022NHLBI NIH HHS R01 HL142118
6 · The paper itself

Abstract

Background: People living with HIV (PLWH) commonly have sleep disturbances, but little is known about their habitual sleep patterns and rest-activity rhythms (RARs). We sought to compare sleep and RAR metrics between people living with and without HIV. Methods: Adult participants with (n = 106) and without HIV (n = 105) underwent evaluation with 14 days of wrist actigraphy. PLWH were virally suppressed and on stable antiretroviral therapy for at least 1 year before evaluation. Sleep duration, timing, regularity, and RAR metrics were derived from actigraphy. Differences in sleep and RAR metrics by HIV status were compared using multivariable regression adjusting for age, sex, race, body mass index, education, employment, smoking, alcohol, and sleep apnea severity. Results: In adjusted analyses, PLWH had later timing of sleep and activity compared with those without HIV (sleep midpoint 38.9 ± 12.7 minutes later, Conclusions: PLWH have delayed, less consolidated, and less robust sleep and RARs compared with those without HIV, suggesting intrinsic differences in circadian rhythms. Future research should evaluate the impact of these abnormalities on long-term health outcomes in PLWH.

Indexed as

HIVobstructive sleep apnearest and activity rhythmssleep

Identifiers

PMID40904473
PMCPMC12402686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.