ReviewFrontiers in immunology2025
Advances in the study of TIM3 in myelodysplastic syndrome.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cell-type specificity of Tim-3 in respiratory diseases: from mechanisms to clinical translation.Frontiers in immunology · 2026Pooled it
- Review
- TIM-3 in AML: pathogenic roles and therapeutic targetability.Clinical and experimental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myelodysplastic syndromes (MDS) are heterogeneous myeloid clonal disorders derived from hematopoietic stem cells. The incidence of MDS (1.51/100,000 in China, 4-5/100,000 in Europe and America) is higher than any subtype of leukemia. In recent years, the imbalance of immune regulation and tumor microenvironmental disorders have received increasing attention in the pathogenesis of MDS. T-cell immunoglobulin and mucin-domain containing protein 3 (TIM-3) is an important inhibitory immune checkpoint molecule, widely expressed in T cells, NK cells, and dendritic cells, monocytes/macrophages and other immune cells. Numerous studies have confirmed that TIM-3 is aberrantly expressed in a variety of solid and hematologic tumors and plays an important role in regulating tumor escape and immune depletion. In this paper, we focus on reviewing the relevant studies of TIM-3 in MDS and summarize the findings of our team in this field. We also discuss the potential application of TIM-3 in the diagnosis and treatment of MDS in conjunction with the latest clinical trials. Blocking TIM-3 has both 'tumor cell-targeted inhibition' and 'immune function remodeling' dual roles in MDS disease progression, which provides new therapeutic strategies and hope for MDS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.