Evidence map›Paper›PMID 40904463›Full record

ArticleFrontiers in immunology2025

Association between neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and psoriasis risk: a nationally representative cross-sectional study.

Huazheng Liang, Wenyue Si, Huilan Huang, Lin Li, Xin Li, Kaiying Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huazheng Liang *Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou Medical University, Guangzhou, China.
Wenyue Si *Department of Science Research and Education Management, Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou Medical University, Guangzhou, China.
Huilan HuangThe Second School of Clinical Medicine, Guangzhou Medical University, Guangzhou, China.
Lin LiDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Xin LiLaboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Kaiying YangDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and the risk of psoriasis. Methods: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) for the periods 2003-2006 and 2009-2014, including 21,723 adults aged ≥20 years. Weighted multivariable logistic regression models were used to examine the association between NHR and psoriasis, with stepwise adjustments for demographic, metabolic parameters, and comorbid factors. Subgroup analyses, sensitivity analyses and smoothed curve fitting were conducted to assess the robustness and potential nonlinearity of the association. Results: The prevalence of psoriasis was 2.75%. Multivariable regression revealed a significant positive association between elevated NHR levels and psoriasis risk (unadjusted model: OR = 1.11, 95% CI = 1.06-1.16, Conclusion: Higher NHR levels are independently associated with an increased risk of psoriasis. Further prospective cohort studies and mechanistic experiments are needed to validate its predictive performance and potential role in psoriasis risk stratification and monitoring.

Indexed as

Cholesterol, HDLNeutrophilsPsoriasisAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceRisk FactorsUnited StatesYoung AdultBiomarkersCholesterol, HDLcross-sectional studyhigh-density lipoprotein cholesterolnational health and nutrition examination surveyNHRpsoriasis

Identifiers

PMID40904463
PMCPMC12401981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.