Evidence map›Paper›PMID 40904462›Full record

ArticleFrontiers in immunology2025

GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice.

Gholamreza Azizi, Javad Rasouli, Hamed Naziri, Michael V Gonzalez, James Garifallou, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Gholamreza AziziDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Javad RasouliDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Hamed NaziriDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Michael V GonzalezCenter for Cytokine Storm Treatment and Laboratory, University of Pennsylvania, Philadelphia, PA, United States.
James GarifallouDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Guang-Xian ZhangDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Bogoljub CiricDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Abdolmohamad RostamiDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.

Funding

ThGM Cells in CNS AutoimmunityR01AI155974 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI A.M. Rostami · 2021 to 2026
$1.9M
NIAID NIH HHS R01 AI155974
6 · The paper itself

Abstract

Introduction: GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice. Methods: We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS). Results: The GM-CSF expression patterns varied by cell type and organ, with CD4 Discussion: These findings identified distinct GM-CSF cellular sources across organs, highlighting the transient nature of GM-CSF expression and the correlation between its expression and the overall phenotype of effector memory CD4

Indexed as

AutoimmunityEncephalomyelitis, Autoimmune, ExperimentalGranulocyte-Macrophage Colony-Stimulating FactorNeuroinflammatory DiseasesAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalMiceMice, Inbred C57BLMice, TransgenicGranulocyte-Macrophage Colony-Stimulating FactorCD4+ T cellsCXCR6experimental autoimmune encephalomyelitisfate reportingGM-CSFneuroinflammation

Identifiers

PMID40904462
PMCPMC12401695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.