Evidence map›Paper›PMID 40904364›Full record

ArticleFrontiers in medicine2025

Metformin may alter the course of Leber's hereditary optic neuropathy: a case report.

Shenoda Abd Elmaseh, Danielle A Gauthier, Maryam Golmohammadi, Nutsa Pargalava, Valerio Carelli, Alfredo A Sadun

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shenoda Abd ElmasehDepartment of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, United States.
Danielle A GauthierDepartment of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, United States.
Maryam GolmohammadiDepartment of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, United States.
Nutsa PargalavaDepartment of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, United States.
Valerio CarelliDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Alfredo A SadunDepartment of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leber's hereditary optic neuropathy (LHON) is a rare inherited mitochondrial disease caused by variants in mitochondrial DNA (mtDNA) transmitted exclusively through the maternal line. The disease predominantly affects young males and is characterized by progressive bilateral vision loss. Idebenone, a well-studied drug, modestly enhances the mitochondrial function and visual acuity in many patients with LHON. In this study, we report the case of a 48-year-old woman diagnosed with LHON (m.11778G>A/

Indexed as

idebenoneLHONmetforminmitochondrial dysfunctionNAD+vision Loss

Identifiers

PMID40904364
PMCPMC12401965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.