Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.

Viana Q Pham, Melike Tutunculer, Halah Al-Dulaimi, Daniel Ardjmand, William Fleischmann, Tomas P Bachor, Allison W Xu

Abstract read

In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Viana Q PhamDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

Melike TutunculerDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

Halah Al-DulaimiDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

Daniel ArdjmandDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

William FleischmannDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

Tomas P BachorDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

Allison W XuDiabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a blood-brain barrier (BBB), play a crucial role in controlling substance exchange between the brain and the blood. To date, adaptive changes in fenestrated vasculature in response to environmental insults remain poorly understood. In this study, we show that fenestrated capillaries in the median eminence (ME) and area postrema (AP)-two distinct circumventricular organs critical for metabolic control-undergo differential remodeling when exposed to circulating monosodium glutamate (MSG), a BBB-impermeable neurotoxin. Upon MSG exposure, fenestrated capillaries and vascular permeability were decreased in the ME but increased in the AP, and these changes were closely associated with the expression of angiogenic factors pleiotrophin (

Indexed as

agingarea postremacircumventricular organsfenestrated capillariesmedian eminencePTNtanycytesVEGF

Identifiers

PMID40904345

DOI10.3389/fnagi.2025.1634283

PMCPMC12401994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.