ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2025
Modified DNA substrate selectivity by GmrSD-family Type IV restriction enzyme BrxU.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- DNA modifications of Durham Collection phages and promiscuity of GmrSD-family Type IV restriction enzyme BrxU.Applied and environmental microbiology · 2026Article
- Developing High-Efficiency Electroporation Protocols for Hard-To-Transform Halomonas spp.Microbial biotechnology · 2025Article
- Preface: the ecology and evolution of bacterial immune systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Bacteriophages (phages), viral predators of bacteria, generate selection pressure that causes bacteria to evolve defence systems. Type I, II and III restriction enzymes cleave incoming non-modified phage DNAs. Phages have evolved to defend against these restriction systems by modifying their DNA so that they are no longer suitable substrates. Type IV restriction enzymes have evolved to recognize and cleave modified DNA. We have recently characterized and solved the first structure for the Type IV GmrSD-family enzymes, using the BrxU homologue from
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