Evidence map›Paper›PMID 40904056›Full record

ArticleMedical physics2025

Biodistribution and dosimetry of

Praveen Dassanayake, Diksha Diksha, Gabriel Varela-Mattatall, Qin Sun, Sarah C Donnelly, Mojmir Suchy, Dianne Bartolome, Shaena Furlong, Lela Deans, Heather Biernaski and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biodistribution and dosimetry ofMedical physics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Praveen DassanayakeImaging Program, Lawson Research Institute, London, Canada.
Diksha DikshaImaging Program, Lawson Research Institute, London, Canada.
Gabriel Varela-MattatallImaging Program, Lawson Research Institute, London, Canada.
Qin SunImaging Program, Lawson Research Institute, London, Canada.
Sarah C DonnellyImaging Program, Lawson Research Institute, London, Canada.
Mojmir SuchyImaging Program, Lawson Research Institute, London, Canada.
Dianne BartolomeImaging Program, Lawson Research Institute, London, Canada.
Shaena FurlongImaging Program, Lawson Research Institute, London, Canada.
Lela DeansImaging Program, Lawson Research Institute, London, Canada.
Heather BiernaskiImaging Program, Lawson Research Institute, London, Canada.
Yvonne HustonImaging Program, Lawson Research Institute, London, Canada.
R Terry ThompsonImaging Program, Lawson Research Institute, London, Canada.
Jeremy P BurtonMicrobiology & Immunology, Western University, London, Canada.
Gerald MoranSiemens Healthcare Limited, Oakville, Canada.
Neil GelmanImaging Program, Lawson Research Institute, London, Canada.
Frank S PratoImaging Program, Lawson Research Institute, London, Canada.
Mike S KovacsImaging Program, Lawson Research Institute, London, Canada.
Jonathan D ThiessenImaging Program, Lawson Research Institute, London, Canada.
Donna E GoldhawkImaging Program, Lawson Research Institute, London, Canada.
James SchellenbergCubresa Inc., Winnipeg, Canada.
Matthew S FoxImaging Program, Lawson Research Institute, London, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gastrointestinal (GI) microbiota, composed of diverse microbial communities, is essential for physiological processes, including immune modulation. Strains such as Escherichia coli Nissle 1917 support gut health by reducing inflammation and resisting pathogens. Microbial therapies using such strains may restore GI balance and offer alternatives to antibiotics, whose overuse contributes to antibiotic resistance. However, effective treatment will require optimizing delivery and understanding microbial dissemination and engraftment. PURPOSE: We developed a method to monitor microbial migration and GI permeability post-ingestion using hybrid PET/MRI. To simulate probiotic therapy, bacteria were radiolabeled with

methodsWe administered

resultsPET imaging showed

conclusionsThe whole-body ED for L. crispatus and E. coli is lower than reported values for ingested tracers, such as that from

Indexed as

Gastrointestinal MicrobiomeRadioisotopesZirconiumAnimalsEscherichia coliFemaleIsotope LabelingMagnetic Resonance ImagingPositron-Emission TomographyRadiometrySwineTissue DistributionRadioisotopesZirconiumZirconium-8989Zr‐labeled bacteriaPET/MRIprobiotic imaging

Identifiers

PMID40904056
PMCPMC12409196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.