Evidence map›Paper›PMID 40903961›Full record

ArticleNeural regeneration research2026

The arginine-phenylalanine-amide neuropeptide receptor family: Physiological effects, drug development, and structural insights.

Yiming Liu, Shirui Jiang, Zhangsong Wu, Chen Qiu, Qiaohui Li, Rui Wang, Xiaoyi Yan, Song Wu, Geng Chen, Yang Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiming LiuKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.
Shirui JiangThe Huanan Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, China.
Zhangsong WuKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.
Chen QiuKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.
Qiaohui LiBiological Science Research Center, Academy for Advanced Interdisciplinary Studies, Southwest University, Chongqing, China.
Rui WangKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.
Xiaoyi YanKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.
Song WuThe Huanan Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, China.ORCID 0000-0003-3504-1630
Geng ChenKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.ORCID 0000-0001-6209-301
Yang DuKobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China.ORCID 0000-0001-5115-0736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation. These receptors recognize and bind neuropeptides with an arginine-phenylalanine-amide motif, thereby participating in a variety of biological processes such as energy metabolism, pain perception, and reproductive functions. In this review, we explore the physiological and pathological processes involving these receptors and delve into the structure-activity relationships of their ligand peptides, clarifying the key structural motifs within these neuropeptides that determine their biological activity, pharmacological potency, and receptor selectivity. Particular emphasis is placed on their roles in modulating nociception, regulating appetite, and maintaining reproductive health. Additionally, we discuss the therapeutic potential of structure-based drug design targeting these receptors based on existing cryo-electron microscopy structures. The available structural insights into ligand-binding pockets and G protein-receptor interaction interfaces provide a clear perspective and valuable complement to ligand optimization.

Indexed as

appetite regulationarginine–phenylalanine–amidedrug discoveryG protein-coupled receptornerve regenerationneuropeptidespain modulationstructure–activity relationship

Identifiers

PMID40903961
PMCPMC13452697

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.