ReviewJournal of neuroimaging : official journal of the American Society of Neuroimaging
Reliability and Spatial Consistency of MR Diffusion Tensor Imaging Measures Along the Cerebral Perivascular Space.
Review in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- DTI-ALPS as a marker of glymphatic function: Review of the literature findings, methodology, and interpretation.Neuroimage. Reports · 2026Article
- Anatomical determinants of DTI-ALPS: effects of ROI definition, ventricular morphology, and periventricular deformation.bioRxiv : the preprint server for biology · 2026Article
- Glymphatic dysfunction is associated with cognitive impairment in white matter hyperintensities: A DTI-based study.IBRO neuroscience reports · 2026Article
- Individualized DTI-ALPS Identifies Phase-Specific Glymphatic Dysfunction in Early-Stage Bipolar Disorder.Biomedicines · 2026Article
- Disease-specific patterns of glymphatic-related dysfunction between multiple sclerosis and neuromyelitis optica spectrum disorder.Frontiers in immunology · 2026Article
- Reliability and Spatial Consistency of MR Diffusion Tensor Imaging Measures Along the Cerebral Perivascular Space.Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
- Longitudinal changes in the ALPS index and its clinical correlates in patients with basal ganglia hemorrhage.Frontiers in neurologyArticle
- Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
10 authors.
Funding
Abstract
background and purposeDiffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a promising noninvasive method for evaluating water motion that may reflect glymphatic system function. However, the reliability of DTI-ALPS measurements across different region-of-interest (ROI) selection methods remains underinvestigated. This study aimed to assess the interrater reliability among three neuroradiologists in native space and compare DTI-ALPS indices derived from ROIs placed in subjects' native space versus standardized Montreal Neurological Institute (MNI) space.
methodsDTI-ALPS indices from 16 healthy subjects were calculated from both left and right hemispheres using two ROI placement approaches: (1) native space ROIs manually placed by three neuroradiologists, and (2) standardized ROIs in MNI space based on the fractional anisotropy template. Interrater reliability was assessed using intraclass correlation coefficients (ICCs). The proportion of ROI overlaps among the three neuroradiologists was also evaluated. Differences between native and MNI space measurements were evaluated using related-samples Friedman's analysis with post hoc pairwise comparisons.
resultsInterrater reliability for native space ROI placement was moderate for left-sided DTI-ALPS indices (ICC = 0.599) and good for right-sided DTI-ALPS indices (ICC = 0.807). Spatial overlap analysis revealed poor Dice similarity coefficients across all ROI types (range: 0.047-0.312), with right association ROIs showing higher spatial consistency. Significant differences were found between native and MNI space measurements for left-sided DTI-ALPS indices (p = 0.002) but not for right-sided DTI-ALPS indices (p = 0.913).
conclusionThese findings highlight the importance of standardized ROI selection approaches for clinical applications of DTI-ALPS.
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