Evidence map›Paper›PMID 40903800›Full record

Trial reportObesity (Silver Spring, Md.)2025

Effects of Whole-Body Cryotherapy Combined With Conventional Obesity Management Versus Obesity Management Alone: A Clinical Trial.

Jari E Karppinen, Laura Suojanen, Sini Heinonen, Sanna Kaye, Birgitta W van der Kolk, James W White, Janne Orava, Seung Hyuk T Lee, Eugené Dillon, Maheswary Muniandy and 6 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01312090 (Chronic Intermittent Cold Exposure on Weight Loss), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01312090 nacompletednot on this map

Chronic Intermittent Cold Exposure on Weight Loss

TypeinterventionalSponsorHelsinki University Central HospitalRan2010 to 2011Enrolled20ConditionsObesityArmsWhole body cryotherapy, counseling and behavioral therapy for weight loss
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jari E KarppinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-9886-9067
Laura SuojanenHealthy Weight Hub, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sini HeinonenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-6342-0577
Sanna KayeObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Birgitta W van der KolkObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
James W WhiteDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-1422-5812
Janne OravaTurku PET Centre, University of Turku, Turku, Finland.
Seung Hyuk T LeeDepartment of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-0943-6076
Eugené DillonMass Spectrometry Core Facility, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Maheswary MuniandyObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Aila RissanenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Carel W le RouxDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-5521-5445
Neil DochertyDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA.
Kirsi A VirtanenTurku PET Centre, University of Turku, Turku, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Funding

Academy of Finland 259926Academy of Finland 265204Academy of Finland 266286Academy of Finland 272376Academy of Finland 292839Academy of Finland 314383Academy of Finland 314456Academy of Finland 335443Academy of Finland 335446Academy of Finland 361956DiabetestutkimussäätiöEuropean Commission 278373Government Research FundsInstrumentariumin TiedesäätiöNovo Nordisk Fonden NNF10OC1013354Novo Nordisk Fonden NNF17OC0027232Novo Nordisk Fonden NNF20OC0060547Novo Nordisk Fonden NNF23SA0083953Orionin TutkimussäätiöPaulon SäätiöSigne ja Ane Gyllenbergin SäätiöSigrid Juséliuksen SäätiöSuomen Lääketieteen SäätiöUniversity of Helsinki and Helsinki University Hospital
6 · The paper itself

Abstract

objectiveTo investigate whether whole-body cryotherapy (WBC) enhances weight loss, brown adipose tissue (BAT) activation, and metabolic outcomes during obesity management.

methodsNineteen adults with obesity were assigned to a 12-month lifestyle-based obesity management intervention with 28 WBC sessions (-110°C, 3-4 min, ~2 × week) over the first 5 months (CRYO, n = 10) or the intervention without WBC (CON, n = 9). The primary outcome was weight loss (5 and 12 months). Secondary outcomes included BAT glucose uptake and whole-body energy expenditure during cold stimulation (5 months), clinical parameters, subcutaneous adipose tissue transcriptomics, and skeletal muscle proteomics (5 and 12 months).

resultsWeight loss in the CRYO group was 11.9% at 5 months and 9.9% at 12 months, compared to 11.5% and 8.0% in the CON group (p ≥ 0.54 for between-group differences). No significant between-group differences appeared in BAT glucose uptake, energy expenditure, adipose tissue transcriptomics, or skeletal muscle proteomics changes. However, at 5 months, the CRYO group showed greater reductions in fasting glucose (0.41 mmol/L, p = 0.026) and LDL cholesterol (0.44 mmol/L, p = 0.034).

conclusionsWBC did not significantly enhance weight loss, activate BAT, or alter most metabolic responses during conventional obesity management. Further research is needed to confirm whether WBC benefits glucose and cholesterol metabolism.

trial registrationClinicalTrials.gov: NCT01312090.

Indexed as

CryotherapyObesityObesity ManagementAdipose Tissue, BrownAdultBlood GlucoseEnergy MetabolismFemaleHumansMaleMiddle AgedMuscle, SkeletalTreatment OutcomeWeight LossBlood Glucosebrown adipose tissuecold exposureenergy metabolismweight loss

Identifiers

PMID40903800
PMCPMC12559775

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.