Evidence map›Paper›PMID 40903799›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Dynamic Profiling of Lipoteichoic Acid (LTA) and/or Lipopolysaccharide (LPS) Positive Extracellular Vesicles in Plasma as Diagnostic and Prognostic Biomarkers for Bacterial Infection.

Qianqian Gao, Wenwu Zhou, Nadira Nurxat, Ke Xu, Yunyun Xu, Wei Li, Tianchi Chen, Cong Hu, Liang Dong, Qian Liu and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qianqian GaoDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.ORCID https://orcid.org/0009-0006-3962-3784
Wenwu ZhouDepartment of neurosurgery, West China Second University Hospital, Sichuan University, Chengdu, 610044, China.
Nadira NurxatDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Ke XuDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Yunyun XuDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Wei LiDepartment of cardiovascular surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Tianchi ChenDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Cong HuDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Liang DongDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Qian LiuDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Min LiDepartment of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.ORCID https://orcid.org/0000-0003-0578-7538

Funding

Key Technologies Research and Development Program 2023YFC2306200National Natural Science Foundation of China 82172325National Natural Science Foundation of China 82402733National Natural Science Foundation of China W2411070Natural Science Foundation of Shanghai Municipality 24ZR1444300
6 · The paper itself

Abstract

Bacterial extracellular vesicles (EVs) are emerging as promising biomarkers for diagnosing bacterial infections. This study explores the diagnostic potential of plasma EVs carrying bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA). Using immunoelectron microscopy (IEM) and nanoflow cytometry (nano-FCM), LTA is confirmed on cytoplasmic membrane vesicles (CMVs) from Gram-positive bacteria and LPS on outer membrane vesicles (OMVs) from Gram-negative bacteria, and quantified LTA-positive or LPS-positive (LTA

Indexed as

Bacterial InfectionsExtracellular VesiclesLipopolysaccharidesTeichoic AcidsAnimalsBiomarkersFemaleHumansMaleMiceMiddle AgedPrognosisBiomarkersLipopolysaccharideslipoteichoic acidTeichoic Acidsbacterial infectionbiomarkersextracellular vesicleslipopolysaccharidelipoteichoic acid

Identifiers

PMID40903799
PMCPMC12667508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.