ArticleJournal of nanobiotechnology2025
Separable cryo-microneedle patches delivery with capsaicin integrated mesoporous dopamine for obesity treatment.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- NIR-elicited nanoplatform amplifies cancer ferrotherapy in uveal melanoma via synergistic ferroptosis induction and glucose metabolism intervention.Materials today. Bio · 2026Article
- Recent progress of NIR light-controlled microneedles and therapeutic applications: A review study.Journal of materials science. Materials in medicine · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
Microneedle patch encapsulated with active medication holds significant potential promise in the realm of anti-obesity therapy. Nevertheless, the improvement of actives delivery efficiency remains a significant challenge. In this paper, we present novel separable cryo-microneedles patches delivered with capsaicin integrated mesoporous dopamine (mPDA) for obesity treatment through activating TRPV1 and inducing lipid droplet dissolution. Such patch is fabricated by cryogenic molding of biocompatible hydrogel tips, which can be easily inserted and left from skin through the thermoresponsive backing layer. Upon penetration, these tips could release mPDA-carrying capsaicin into the targeted subcutaneous adipose layer. In addition, when exposed to near infrared (NIR) light, these mPDA could rapidly convert the light energy into heat to increase the local temperature, thus accelerating the release of capsaicin from mPDA and the metabolic benefits of regional hyperthermia therapy. Based on these features, we have demonstrated that the multifunctional separated cryo-microneedles could significantly reduce weight and relieve obesity-associated pathological conditions with no adverse effect through an 8-week observation on high-fat diet (HFD) mice. Thus, we believe that our separable cryo-microneedles patches delivered with capsaicin integrated mPDA will open a new prospect for obesity treatment.
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Registered trials
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