ArticleMicrobial cell factories2025
Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities.
Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production. Thus, exploring of a fungal isolate with a reliable robustness for Taxol biosynthesis is the objective of this study. Although, Encephalartos bubalinus has diverse ethnopharmaceutical properties, however, the identity of its endophytic fungi remains poorly explored. Therefore, the endophytic fungi inhabiting this plant has been isolated and characterized, and their Taxol productivity was assessed. Amesia nigricolor OR364127.1, an endophyte of E. bubalinus, was characterized as the potent biologically active and Taxol producer (105 μg/l). The sample identity was resolved from the HPLC, FT-IR and MS/MS analysis, with the molecular mass/ fragmentation pattern was identical to authentic one. The extracted Taxol of A. nigricolor had a strong activity against the HepG2 (IC
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