Evidence map›Paper›PMID 40903632›Full record

ReviewStem cell reviews and reports2025

Advancements in Chitosan and Cellulose Nanoparticles for Stem Cell-Based Tissue Engineering.

Zafar Aminov, Harikumar Pallathadka, Muthena Kareem, Lalji Baldaniya, Dmitry Olegovich Bokov, Mamata Chahar, Suman Saini, Ish Kapila, Yasser Fakri Mustafa, Israa Habeeb Naser

Abstract readReview
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In one paragraph

Review in Stem cell reviews and reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zafar AminovDepartment of Public Health and Healthcare management, Samarkand State Medical University, 18 Amir Temur Street, Samarkand, Uzbekistan.
Harikumar PallathadkaManipur International University, Imphal, Manipur, India. harikumar@miu.edu.in.ORCID 0000-0002-0705-9035
Muthena KareemDepartment of medical analysis, Medical laboratory technique college, the Islamic University, Najaf, Iraq.
Lalji BaldaniyaDepartment of Pharmacy, Faculty of Health Sciences, Marwadi University, Rajkot, 360003, Gujarat, India.
Dmitry Olegovich BokovInstitute of Pharmacy named after A.P. Nelyubin, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation.ORCID 0000-0003-2968-2466
Mamata ChaharDepartment of Chemistry, NIMS Institute of Engineering & Technology, NIMS University Rajasthan, Jaipur, India.
Suman SainiDepartment of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of Colleges-Jhanjeri, Mohali140307, Punjab, India.
Ish KapilaCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.ORCID 0000-0002-0926-7428
Israa Habeeb NaserMedical Laboratories Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, Babylon, 51001, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell-based tissue engineering offers transformative solutions for regenerating damaged tissues, such as bone, cartilage, and neural tissues. Chitosan and cellulose nanoparticles have emerged as promising biomaterials for enhancing stem cell delivery and scaffold performance due to their biocompatibility, biodegradability, and tunable properties. Chitosan, with its antimicrobial and bioadhesive properties, supports stem cell adhesion and differentiation in soft tissue scaffolds. Cellulose nanoparticles, including cellulose nanocrystals (CNCs), nanofibrils (CNFs), and bacterial nanocellulose (BNC), provide mechanical strength for hard tissue regeneration. This review examines their synthesis, properties, and interactions with stem cells, particularly mesenchymal stem cells (MSCs), in tissue engineering applications. A comparative analysis highlights their complementary roles, while challenges like physiological stability and scalability are addressed. Recent advancements, such as 3D bioprinting and growth factor functionalization, enhance their potential. Future research should focus on optimizing stem cell-scaffold interactions and ensuring clinical safety.

Indexed as

CelluloseChitosanMesenchymal Stem CellsNanoparticlesStem CellsTissue EngineeringAnimalsBiocompatible MaterialsCell DifferentiationHumansTissue ScaffoldsBiocompatible MaterialsCelluloseChitosanBiocompatibilityCellulose nanoparticlesChitosan nanoparticlesMesenchymal stem cellsScaffoldsStem Cell-Based tissue engineering

Identifiers

PMID40903632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.