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ArticleEuropean radiology2026

Dual-energy based myocardial extracellular volume quantification with photon-counting detector and energy-integrating detector dual-source computed tomography: comparison with cardiac magnetic resonance.

Shouyu Bao, Mi Zhou, Mengzhen Wang, Zhihan Xu, Fuhua Yan, Wenjie Yang

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

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1citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shouyu Bao *Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mi Zhou *Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengzhen WangDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhihan XuCT Collaboration, Siemens Healthineers, Shanghai, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenjie YangDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lisa_ywj@163.com.ORCID http://orcid.org/0000-0002-3959-5043

Funding

National Key Research and Development Program of China 2022YFC2401604
6 · The paper itself

Abstract

objectivesThis study compared three-dimensional myocardial extracellular volume (ECV) quantification among single-phase and dual-phase photon-counting detector computed tomography (PCD-CT) and dual-phase energy-integrating detector computed tomography (EID-CT), using cardiac magnetic resonance (CMR) imaging as the reference. MATERIALS AND

methodsThis retrospective study included 80 patients who underwent both CMR and cardiac CT (40 patients underwent PCD-CT and 40 underwent EID-CT). Pearson correlation coefficients and intraclass correlation coefficients (ICCs) were used to evaluate the correlation and reliability of CT-ECV with CMR-ECV. Subgroup analysis was performed based on heart rate.

resultsThe single-phase and dual-phase ECV measurements on PCD-CT showed excellent correlation and consistency with CMR (correlation coefficient: single-phase, 0.84; dual-phase, 0.91; ICC: single-phase, 0.90; dual-phase, 0.94). Both methods significantly outperformed EID-CT (correlation coefficient: 0.62; ICC: 0.76; all p < 0.05). No significant differences were observed between the two PCD-CT methods (all p > 0.05). PCD-CT demonstrated high consistency across both HR subgroups (ICC: HR ≤ 60 bpm: 0.89 for single-phase, 0.85 for dual-phase; HR > 60 bpm: 0.87 for single-phase, 0.88 for dual-phase), whereas EID-CT exhibited reduced consistency in patients with HR > 60 bpm (ICC: HR ≤ 60 bpm: 0.78; HR > 60 bpm: 0.60).

conclusionCompared with EID-CT, PCD-CT showed superior correlation and reliability for myocardial ECV quantification, particularly in patients with elevated heart rates. The single-phase PCD-CT method demonstrated performance equivalent to the dual-phase approach. KEY POINTS: Question How does myocardial ECV quantification using PCD-CT compare with conventional EID-CT? Findings Single-phase and dual-phase methods on PCD-CT significantly outperform EID-CT in myocardial ECV quantification. Clinical relevance These findings suggest PCD-CT significantly outperforms EID-CT as a promising alternative to CMR for myocardial ECV assessment, particularly under challenging conditions such as higher heart rates, offering improved reliability for clinical myocardial tissue characterization.

Indexed as

HeartMagnetic Resonance ImagingMyocardiumTomography, X-Ray ComputedAdultAgedFemaleHumansImaging, Three-DimensionalMaleMiddle AgedReproducibility of ResultsRetrospective StudiesComputed tomographyExtracellular volumeMyocardiumPhoton-counting detector computed tomography

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.