Evidence map›Paper›PMID 40903621›Full record

ArticleActa parasitologica2025

Analysis of the Behavior of Trypanosoma cruzi in Culture Against Different Dosage Forms of Benznidazole: Experimental Insights.

Jaime López-Domínguez, Aracely López-Monteon, Paulina Ochoa-Martínez, Josue Rafael González-García, Rodolfo Peña-Rodríguez, Etienne Waleckx, Joel Moo-Millán, Angel Ramos-Ligonio

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Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaime López-DomínguezLADISER Inmunología y Biología Molecular, Edificio D, Facultad de Ciencias Químicas, Universidad Veracruzana (UV), Prolongación de Oriente 6 #1009, Colonia Rafael Alvarado, C.P. 94340, 86039, Orizaba, Veracruz, Mexico.
Aracely López-MonteonLADISER Inmunología y Biología Molecular, Edificio D, Facultad de Ciencias Químicas, Universidad Veracruzana (UV), Prolongación de Oriente 6 #1009, Colonia Rafael Alvarado, C.P. 94340, 86039, Orizaba, Veracruz, Mexico.
Paulina Ochoa-MartínezLADISER Inmunología y Biología Molecular, Edificio D, Facultad de Ciencias Químicas, Universidad Veracruzana (UV), Prolongación de Oriente 6 #1009, Colonia Rafael Alvarado, C.P. 94340, 86039, Orizaba, Veracruz, Mexico.
Josue Rafael González-GarcíaLADISER Inmunología y Biología Molecular, Edificio D, Facultad de Ciencias Químicas, Universidad Veracruzana (UV), Prolongación de Oriente 6 #1009, Colonia Rafael Alvarado, C.P. 94340, 86039, Orizaba, Veracruz, Mexico.
Rodolfo Peña-RodríguezLADISER Química Órganica, Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz, Mexico.
Etienne WaleckxAsociacion Chagas con Ciencia y Conocimiento A.C., Orizaba, Veracruz, Mexico.
Joel Moo-MillánLaboratorio de parasitología, Centro de Investigaciones Regionales Hideyo Nuguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
Angel Ramos-LigonioLADISER Inmunología y Biología Molecular, Edificio D, Facultad de Ciencias Químicas, Universidad Veracruzana (UV), Prolongación de Oriente 6 #1009, Colonia Rafael Alvarado, C.P. 94340, 86039, Orizaba, Veracruz, Mexico. angramos@uv.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to investigate the influence of benznidazole (BZN) origin on its in vitro potency against various Trypanosoma cruzi strains.

methodsPure BZN, purified BZN, and the pharmaceutical formulation Abarax were evaluated for their activity against several parasite strains.

resultsResults demonstrated significant variability in BZN's effectiveness, contingent upon both its specific form and the T. cruzi strain under investigation. Half-maximal inhibitory concentrations (IC

conclusionIn conclusion, this study elucidates the complex interaction between BZN and T. cruzi. The parasite's response to BZN can vary even within a single strain, influenced by the drug's specific presentation. These findings underscore the critical importance of considering both parasite diversity and drug formulation when assessing the efficacy of treatments in laboratory assays.

Indexed as

NitroimidazolesTrypanocidal AgentsTrypanosoma cruziAnimalsInhibitory Concentration 50Parasitic Sensitivity TestsbenzonidazoleNitroimidazolesTrypanocidal AgentsBenznidazoleDrug potencyDrug sensitivityDTU´sTreatmentsTrypanosoma cruzi

Identifiers

PMID40903621

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.