ArticleNature2025
Amygdala-liver signalling orchestrates glycaemic responses to stress.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs.The international journal of neuropsychopharmacology · 2026Article
- Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The Amygdala and Politics.Brain sciences · 2026Review
- Review
- MASH-Associated T Cell Activation and Neuroinflammation: Evidence for a Hepatosystemic Immune Axis.Seminars in liver disease · 2026Review
- GABA signaling in NG2 glia mediates empathy-like behavior under observational social defeat.Nature communications · 2026Article
- Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling.Science advances · 2026Article
- Hepatic Gluconeogenesis and the Antidepressant Effects of Exercise: A Narrative Review.Metabolites · 2026Review
- Region-resolved proteomic map of the human brain: functional interconnections and neurological implications.Signal transduction and targeted therapy · 2026Article
- Immune Determinants of MASLD Progression: From Immunometabolic Reprogramming to Fibrotic Transformation.Biology · 2026Review
- Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes.Diabetes · 2026Review
- Stress Hyperglycemia Ratio as a Predictor of All-Cause and Cardiovascular Mortality in the General Population: Insights From NHANES 2001-2018.International journal of endocrinology · 2026Article
- Acute Stress Attenuates Hepatic Ischemia-Reperfusion Injury via Hypothalamic CRH Neuron-Induced HPA Axis Activation.CNS neuroscience & therapeutics · 2026Article
Corrections and comments
- Update of
Authors and funding
24 authors.
J R E Carty *Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
K Devarakonda *Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4374-4670
R M O'Connor *Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
A KrekDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
D EspinozaDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M Jimenez-GonzalezDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7678-9058
A AlvarssonDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
R F HamptonDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3285-6957
R LiDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-2605-634X
Y QiuDepartment of Medicine (Division of Endocrinology), Fleischer Institute for Diabetes and Metabolism, The Albert Einstein College of Medicine, Bronx, NY, USA.
S PetriDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
A ShteklerDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
A RajbhandariNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5596-8735
K ConnerDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M BayneDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
D GaribayDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J MartinDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
V LehmannNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
L WangDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
K BeaumontDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-3075-9977
I KurlandDepartment of Medicine (Division of Endocrinology), Fleischer Institute for Diabetes and Metabolism, The Albert Einstein College of Medicine, Bronx, NY, USA.
G C YuanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-2283-4714
P J KennyNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S A StanleyDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.stanley@mssm.edu.ORCID 0000-0002-0253-2663
Funding
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI FLEISCHER, NORMAN S. · 1986 to 2014
$29.8MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MTranscription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ERIC J. NESTLER · 2019 to 2026
$16.5MSingle cell brain transcriptome changes during chronic HIV infection and opiate use in conventional miceU01DA053629 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNY, PAUL J., VOLSKY, DAVID J · 2021 to 2025
$11.1MA regulome and transcriptome atlas of fetal and adult human neurogenesisRF1MH128970 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, LONG, HOF, PATRICK R · 2021 to 2021
$5.5MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MTowards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlasRF1MH133703 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS, YUAN, GUO-CHENG · 2023 to 2023
$2.6MNeural control of pancreatic endocrine function in obesity and diabetesR01DK124461 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STANLEY, SARAH AMY · 2021 to 2024
$2.4MMicroRNAs in schizophreniaR01MH112168 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNY, PAUL J. · 2017 to 2021
$2.1MPancreatic Neural Circuitry in Obesity and DiabetesF31DK129016 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAMPTON, ROLLIE · 2021 to 2023
$144kNIA NIH HHS T32 AG049688NIDA NIH HHS P01 DA047233NIDA NIH HHS U01 DA053629NIDDK NIH HHS F31 DK129016NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK124461NIMH NIH HHS R01 MH112168NIMH NIH HHS RF1 MH128970NIMH NIH HHS RF1 MH133703
Abstract
Behavioural adaptations to environmental threats are crucial for survival
Indexed as
AmygdalaBlood GlucoseLiverSignal TransductionStress, PhysiologicalStress, PsychologicalAnimalsGluconeogenesisGlucoseHomeostasisHyperglycemiaMaleMiceMice, Inbred C57BLNeuronsBlood GlucoseGlucose
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.