Evidence map›Paper›PMID 40903580›Full record

ArticleNature2025

DNA2 enables growth by restricting recombination-restarted replication.

Jessica J R Hudson, Rowin Appanah, David Jones, Kathryn Davidson, Alice M Budden, Alina Vaitsiankova, Kok-Lung Chan, Keith W Caldecott, Antony M Carr, Ulrich Rass

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jessica J R Hudson *Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0003-3189-2622
Rowin Appanah *Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
David JonesGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0009-0009-9173-4109
Kathryn DavidsonGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Alice M BuddenGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0003-1896-3086
Alina VaitsiankovaGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0002-9355-0903
Kok-Lung ChanGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0002-8796-8385
Keith W CaldecottGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0003-4255-9016
Antony M CarrGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0002-2028-2389
Ulrich RassGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK. U.W.Rass@sussex.ac.uk.ORCID 0000-0001-9275-9062

Funding

Wellcome Trust 225348
6 · The paper itself

Abstract

Nuclease-helicase DNA2 is a multifunctional genome caretaker that is essential for cell proliferation in a range of organisms, from yeast to human

Indexed as

DNA HelicasesDNA ReplicationHomologous RecombinationRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAtaxia Telangiectasia Mutated ProteinsCell ProliferationCellular SenescenceDNA DamageDNA, Single-StrandedDwarfismG2 Phase Cell Cycle CheckpointsHumansReplication Protein AAtaxia Telangiectasia Mutated ProteinsATR protein, humanDNA2 protein, humanDNA HelicasesDNA, Single-StrandedReplication Protein ASaccharomyces cerevisiae Proteins

Identifiers

PMID40903580
PMCPMC12545200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.