ArticleNature2025
PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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Who cites it
32 citing papers in PubMed.
- Oxidative stress and inflammation in neurodegenerative disorders.Archives of toxicology · 2026Review
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- A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits.bioRxiv : the preprint server for biology · 2026Article
- Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.Nature communications · 2026Article
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- KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease.iScience · 2026Article
- Circular RNAEnvironment & health (Washington, D.C.) · 2026Article
- A Multi-Context Regulome-Wide Association Atlas for Genetic Studies of Aging Brain Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Astrocytic ACSBG1 depletion improves lipid-cytokine signaling and attenuates α-Synuclein pathology in a Parkinson's disease mouse model.bioRxiv : the preprint server for biology · 2026Article
- Alzheimer's disease biological domain sub-stratification enhances the precision of functional analyses.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
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- How does type 2 diabetes modify the risk of Alzheimer's disease?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The Interplay Between Immunometabolism and Neuroinflammation in Alzheimer's Disease.Biomolecules · 2026Review
- P7C3-A20 prevents whole brain radiotherapy-induced chronic hippocampal redox imbalance and neuropsychiatric impairment in mice.Redox biology · 2026Article
- scTWAS: a powerful statistical framework for single-cell transcriptome-wide association studies.Nature communications · 2026Article
- Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.bioRxiv : the preprint server for biology · 2026Article
- Cellular mechanisms of brain lipid metabolism in health and disease.Nature cell biology · 2026Review
- Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at thebioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
21 authors.
Alena Kozlova *Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.
Siwei Zhang *Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.
Ari Sudwarts *Byrd Alzheimer's Center and Research Institute, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-3816-4380
Hanwen Zhang *Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.ORCID 0000-0001-8490-918X
Stanislau SmirnouByrd Alzheimer's Center and Research Institute, University of South Florida, Tampa, FL, USA.
Seul Kee ByeonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9095-4841
Christina ThapaCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.ORCID 0000-0003-0822-2911
Xiaotong SunDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-4685-9852
Kimberley StephensonCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.
Xiaojie ZhaoCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.
Brendan JamisonCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.
Moorthi PonnusamyByrd Alzheimer's Center and Research Institute, University of South Florida, Tampa, FL, USA.
Xin HeDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9011-5212
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Rush University, Chicago, IL, USA.ORCID 0000-0002-9482-1752
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9943-6127
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Rush University, Chicago, IL, USA.
Zhiping P PangCenter for NeuroMetabolism, Department of Neuroscience and Cell Biology, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID 0000-0002-6183-1233
Alan R SandersCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.ORCID 0000-0001-6629-4011
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5992-5989
Gopal ThinakaranByrd Alzheimer's Center and Research Institute, University of South Florida, Tampa, FL, USA. thinakaran@usf.edu.ORCID 0000-0001-5523-6780
Jubao DuanCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA. jduan@uchicago.edu.ORCID 0000-0002-7215-3220
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MMulti-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7MPathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6MFunctional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila ModelsU01AG072439 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J, BOTAS, JUAN · 2021 to 2025
$8.4MSystematic Functional Interpretation of Regulatory Variants in SchizophreniaR01MH106575 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO · 2016 to 2025
$6.1MMayo Clinic Center for Clinical ProteomicsU01CA271410 · NCI · MAYO CLINIC ROCHESTER · PI Rafael Fonseca, AKHILESH PANDEY · 2022 to 2026
$5.3MModeling Alzheimer's disease genetic variants in hiPSCR01AG063175 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO, THINAKARAN, GOPAL · 2019 to 2023
$3.7MIntegrating epigenomics with DNA breathing dynamics for human non-coding disease variantsR01MH116281 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI ALEXANDROV, BOIAN STOIANOV, DUAN, JUBAO · 2019 to 2023
$3.0MNCI NIH HHS P30 CA015083NCI NIH HHS U01 CA271410NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG063175NIA NIH HHS R01 AG073260NIA NIH HHS R01 AG079141NIA NIH HHS R01 AG081374NIA NIH HHS RF1 AG079141NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG072439NIMH NIH HHS R01 MH106575NIMH NIH HHS R01 MH116281
Abstract
Despite genome-wide association studies (GWAS) of late-onset Alzheimer's disease (LOAD) having identified many genetic risk loci
Indexed as
Alzheimer DiseaseGenetic Predisposition to DiseaseLipid DropletsMicrogliaMonomeric Clathrin Assembly ProteinsAllelesAmyloid beta-PeptidesAnimalsAstrocytesCholesterolChromatinGenetic LociGenome-Wide Association StudyHumansInduced Pluripotent Stem CellsMyelin SheathAmyloid beta-PeptidesCholesterolChromatinMonomeric Clathrin Assembly ProteinsPICALM protein, human
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.