ArticleNature2025
Dynamic fibroblast-immune interactions shape recovery after brain injury.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
–field-weighted citation impact
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Who cites it
27 citing papers in PubMed.
- Collagen Triple Helix Repeat Containing 1 (CTHRC1) in the Nervous System: Expression, Signaling Mechanisms, and Functional Implications.Journal of molecular neuroscience : MN · 2026Review
- Article
- Neonatal small extracellular vesicle-loaded GelNB hydrogel reprograms the vascular-immune microenvironment for spinal cord injury repair.Bioactive materials · 2026Article
- Compartmentalized B cell-microglia crosstalk drives ischemic white matter demyelination.Nature communications · 2026Article
- Cerebrovascular vulnerability and fibrosis in human brain aneurysms.Nature neuroscience · 2026Article
- Eosinophils promote a second wave of postnatal smooth muscle differentiation in intestinal villi.The Journal of cell biology · 2026Article
- Epigenetic mechanisms of inflammatory memory in the central nervous system.Nature immunology · 2026Review
- Review
- The microglia-derived protein Sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish.PLoS biology · 2026Article
- Extracellular matrix remodelling in neurological diseases.Nature reviews. Neurology · 2026Review
- Fibroblasts as regulators of lung immunity, repair and fibrosis.Nature reviews. Immunology · 2026Review
- Lung adventitial fibroblasts support type 2 Tregs to shape the response to influenza infection.bioRxiv : the preprint server for biology · 2026Article
- Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches.Science advances · 2026Article
- Beyond the Glial Scar: Fibroblasts as Dynamic Coordinators of Neuroprotection and Neuroinflammation Post-Brain Injury.Neuroscience bulletin · 2026Article
- From origins to nomenclature: illuminating the landscape of CNS fibroblasts and fibroblast-like cells.Acta neuropathologica communications · 2026Review
- Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Focus on Arginase.Cells · 2026Article
- Monocyte-derived macrophages and their roles in ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Meningeal macrophages regulate fibroblasts to influence meningeal lymphatic function following traumatic brain injury.Theranostics · 2026Article
- Hypoglycemia aggravates cognitive degeneration by activating endothelial ZBP1-mediated PANoptosis in type 2 diabetic mice.Frontiers in pharmacology · 2026Article
- Integrating brain organoids, meningeal immunity, and glymphatic dynamics: toward modeling neuroimmune clearance and crosstalk in disease.Frontiers in immunology · 2026Review
Corrections and comments
- Update of
Authors and funding
34 authors.
Nathan A Ewing-CrystalBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2486-1783
Nicholas M MrozBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4781-8518
Amara LarpthaveesarpDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Carlos O LizamaDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0471-8525
Remy PenningtonDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Pailin ChiaranuntDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8753-1469
Jason I DennisDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Anthony A ChangBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Eric Dean MerrillDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sofia E CaryotakisBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Nikhita KirthivasanBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0005-4864-7799
Leon TeoAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.
Tatsuya TsukuiLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3100-6934
Aditya KatewaDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Gabriel L McKinseyDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Sophia C K NelsonBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0001-9017-8448
Agnieszka CiesielskaGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Nicole C LummisDepartments of Pharmacology and Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Lucija PintarićDepartments of Pharmacology and Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4577-7334
Madelene W DahlgrenDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Amha AtakilitLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Helena PaidassiCentre International de Recherche en Infectiologie (CIRI), Univ Lyon, Inserm, U1111 Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID 0000-0001-9915-4365
Saket JainDepartment of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Xiaodan LiuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Manish K AghiDepartment of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2949-2227
James A BourneAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.
Jeanne T PazGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0001-6339-8130
Richard DanemanDepartments of Pharmacology and Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Fernando F GonzalezDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Dean SheppardLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6277-2036
Anna V MolofskyDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4709-2411
Thomas D ArnoldDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. thomas.arnold@ucsf.edu.ORCID 0000-0002-7310-5597
Ari B MolofskyBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. ari.molofsky@ucsf.edu.ORCID 0000-0003-0764-3175
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MRestorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5MEnhanced cellular therapy for neonatal strokeR01NS107039 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Fernando Francisco Gonzalez · 2018 to 2026
$3.8MFibroblast heterogeneity in pulmonary fibrosisR01HL142568 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHEPPARD, DEAN · 2020 to 2023
$2.9MLocalization and function of tissue type 2 lymphocytes during mixed inflammationR01AI162806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2022 to 2026
$2.8MHow do CNS fibroblasts regulate the response to neuroinflammation?R01NS119615 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DANEMAN, RICHARD · 2021 to 2025
$2.4MMeningeal type 2 immunity in cortical synapse remodeling during brain development and injuryR01NS126765 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anna V Molofsky, Ari B Molofsky · 2022 to 2026
$2.3MDistinct early and late programs of fibroblast - immune crosstalk govern functional responses to brain injuryR01AI180438 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2024 to 2026
$2.3MThe Role of Inflammation in Post-stroke EpileptogenesisR01NS096369 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI PAZ, JEANNE T · 2016 to 2021
$2.3MRole of Myeloid And CD4+ T Immune Cells in Post-Traumatic PlasticityR01NS121287 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI Jeanne T Paz · 2022 to 2026
$2.2MCellular and molecular delineation of pathologic fibroblasts in pulmonary fibrosisR00HL155786 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TSUKUI, TATSUYA · 2023 to 2025
$747kNHLBI NIH HHS R00 HL155786NHLBI NIH HHS R01 HL142568NIAID NIH HHS R01 AI162806NIAID NIH HHS R01 AI180438NIDDK NIH HHS P30 DK063720NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM136547NINDS NIH HHS R01 NS096369NINDS NIH HHS R01 NS107039NINDS NIH HHS R01 NS119615NINDS NIH HHS R01 NS121287NINDS NIH HHS R01 NS126765
Abstract
Fibroblasts and immune cells coordinate tissue regeneration and necessary scarring after injury. In the brain, fibroblasts are border-enriched cells whose dynamic molecular states and immune interactions after injury remain unclear
Indexed as
Brain InjuriesCell CommunicationFibroblastsAnimalsBrainChemokine CXCL12Disease Models, AnimalFemaleInfarction, Middle Cerebral ArteryInterferon-gammaLymphocytesMacrophagesMaleMiceMice, Inbred C57BLMicrogliaChemokine CXCL12Cxcl12 protein, mouseInterferon-gammaTransforming Growth Factor beta
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.