ArticleNature2025
Single-cell transcriptomic and genomic changes in the ageing human brain.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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Who cites it
31 citing papers in PubMed.
- Review
- Review
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- Article
- Integrative transcriptomics identifies shared aging-associated inhibitory-neuron states and prioritizes RGL2 across postoperative delirium and Alzheimer's disease.Journal of molecular neuroscience : MN · 2026Article
- Conserved Partial Reprogramming Effects on the Methylome.Epigenomes · 2026Article
- Article
- A scalable, low-cost, sample hashing workflow for multiomic single-cell analysis using the Seq-Well SNature protocols · 2026Review
- Article
- Advances in the Comprehensive Tree Shrew Brain Atlas.Biomolecules · 2026Review
- Metabolomic signatures of brain aging: A multimodal and genetic study.Molecular psychiatry · 2026Article
- Single-cell multi-omics dissection of RevitalAge Markers uncovers age-dependent immunotherapy resistance and druggable targets in melanoma.Biology direct · 2026Article
- Charting the human-specific properties of gene expression networks in the infant prefrontal cortex.Science advances · 2026Article
- Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis.International journal of stem cells · 2026Review
- Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level.npj aging · 2026Article
- Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Determining the age of single cells using scMLEAge.bioRxiv : the preprint server for biology · 2026Article
- Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform.Scientific reports · 2026Article
- Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
9 authors.
Ailsa M Jeffries *Department of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-6233-4215
Tianxiong Yu *Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1151-4624
Jennifer S ZiegenfussDepartment of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3828-0381
Allie K TollesDepartment of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-5569-0710
Christina E BaerSanderson Center for Optical Experimentation, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8909-2583
Cesar Bautista SoteloDepartment of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-4009-5978
Yerin KimDepartment of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0009-1700-8440
Zhiping WengDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. Zhiping.Weng@umassmed.edu.ORCID 0000-0002-3032-7966
Michael A LodatoDepartment of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA. Michael.Lodato@umassmed.edu.ORCID 0000-0003-4175-1073
Funding
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MResearch Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MA Comprehensive Genomic Community Resource of Transcriptional RegulationU24HG012343 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Anshul Kundaje, Zhiping Weng · 2022 to 2026
$4.6MSpatial single-cell analysis of somatic mutation in human brain during aging and neurodegenerationDP2AG086139 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Michael Anthony Lodato · 2023 to 2026
$2.5MSingle-cell analysis of DNA damage, somatic mutation, and gene expression in human Alzheimer’s disease brainR56AG078453 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LODATO, MICHAEL ANTHONY, WENG, ZHIPING · 2023 to 2023
$836kSINGLE-CELL ANALYSIS OF SOMATIC MUTATION IN AGING ANO NEUROOEGENERATIVE DISEASE IN THE HUMAN BRAINR00AG054748 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LODATO, MICHAEL ANTHONY · 2019 to 2021
$743kBD FACSAriaTM Fusion Fluoresence-Activated Cell SorterS10OD028576 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHRADER, CAROL E · 2020 to 2020
$565kNHGRI NIH HHS U24 HG012343NIA NIH HHS DP2 AG086139NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NIA NIH HHS R00 AG054748NIA NIH HHS R56 AG078453NIH HHS S10 OD028576NINDS NIH HHS U24 NS072026
Abstract
Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process
Indexed as
AgingBrainGenome, HumanGenomicsPrefrontal CortexSingle-Cell AnalysisTranscriptomeAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleGene Expression ProfilingHumans
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.