ArticleNature2025
Rewiring of cortical glucose metabolism fuels human brain cancer growth.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
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Who cites it
38 citing papers in PubMed.
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
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- Microenvironment-derived acetylated amino acids promote glioblastoma treatment resistance.Research square · 2026Article
- Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.Cell · 2026Article
- Dynamic control of nucleotide metabolism in physiology and disease.Nature cell biology · 2026Review
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.Nature cell biology · 2026Review
- GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells.Nature cancer · 2026Article
- TAF15-mediated m5C modification of MTHFD2 RNA reveals a novel therapeutic target for IDH mutant gliomas.Biomarker research · 2026Article
- Patient-derived glioblastoma cultures preserve respiration phenotypes during ex vivo maintenance and show sex-associated differences in migration.Acta neuropathologica communications · 2026Article
- Hp1bp3 loss links chromatin reorganization to metabolic vulnerability in glioma.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- A proteogenomic RNA processing mechanism drives sex differences in meningioma.Research square · 2026Article
- Cancer stem cells synthesize proline to attenuate oxidative stress.The Journal of clinical investigation · 2026Article
- Lactylation in cardiac repair: Nexus and therapeutic opportunity.Journal of molecular and cellular cardiology plus · 2026Review
- Re-evaluating the rationale for targeting oxidative phosphorylation in acute myeloid leukemia.The Biochemical journal · 2026Review
- Conserved principles of central carbon partitioning in Hippo-Yorkie-drivenbioRxiv : the preprint server for biology · 2026Article
- Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.Nature metabolism · 2026Article
- A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- Brain cells refine nitrogen choice with maturity.Nature metabolism · 2026Article
Corrections and comments
- Update of
Authors and funding
41 authors.
Andrew J Scott *Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0835-4888
Anjali Mittal *Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5670-032X
Baharan Meghdadi *Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-8871-1488
Alexandra O'BrienDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Justine BailleulDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Palavalasa SravyaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Abhinav AchrejaRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1773-6490
Weihua ZhouDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0259-0828
Jie XuDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Angelica LinDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Kari Wilder-RomansDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Ningning LiangDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1439-7929
Ayesha U KothariDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Navyateja KorimerlaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Donna M EdwardsDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Zhe WuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Jiane FengDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Sophia SuDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8556-7481
Anthony C AndrenDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Junyoung O ParkDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA.ORCID 0000-0001-9869-8993
Johanna Ten HoeveDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0003-0226-749X
Vijay TarnalDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2795-1610
Kimberly A RedicDepartment of Pharmacy Services, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Nathan R QiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1919-9171
Joshua L FischerBruker Daltonics, Billerica, MA, USA.
Ethan YangBruker Daltonics, Billerica, MA, USA.
Michael S ReganDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5252-2829
Sylwia A StopkaDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gerard BaquerDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Krithika SureshDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Jann N SarkariaDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Theodore S LawrenceDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Sriram VennetiDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Nathalie Y R AgarDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3149-3146
Erina VlashiDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Costas A LyssiotisRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.ORCID 0000-0001-9309-6141
Wajd N Al-HolouRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. wna@med.umich.edu.ORCID 0000-0001-8528-4855
Deepak NagrathRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. dnagrath@umich.edu.ORCID 0000-0002-8999-2282
Daniel R WahlDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. dwahl@med.umich.edu.ORCID 0000-0001-9894-5085
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gary D Luker · 1988 to 2026
$178.2MTranslational Pathology CoreP50CA269022 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE, Meredith A Morgan · 2023 to 2026
$10.0MQuantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieuU54CA283114 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Nathalie YR Agar · 2023 to 2026
$9.7MMetabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK135066 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias · 2023 to 2026
$3.5MTargeting Nucleotide Metabolism to Overcome Therapy Resistance in GlioblastomaR37CA258346 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Daniel R Wahl · 2021 to 2026
$3.3MTargeting integrated metabolic and epigenetic pathways in childhood ependymomasR01CA261926 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Deepak Nagrath, Benita Tamrazi · 2022 to 2026
$3.0MTargeting Stromal Influences on BCKA Addiction in PDAC TumorsR01CA271369 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE, Deepak Nagrath · 2022 to 2026
$2.8MDrivers of Metabolic Plasticity Promote Radiation Resistance in Glioblastoma MultiformeR01CA251872 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VLASHI, ERINA · 2020 to 2024
$2.8MUnravelling metabolic dependencies in H3K27M mutant DIPGR01NS110572 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Venneti · 2019 to 2026
$2.7MMolecular basis linking metabolic heterogeneity, compatibility, and adaptabilityR35GM143127 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Junyoung O. Park · 2021 to 2026
$2.5MInhibition of wild-type IDH1 as a ferroptosis-inducing therapeutic approach for the treatment of malignant glioma.R01NS129123 · NINDS · WASHINGTON UNIVERSITY · PI Alexander H. Stegh, Daniel R Wahl · 2022 to 2026
$2.4MTargeting metabolic dependencies in ZFTA-RELA fusion childhood ependymomasR01NS127799 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Venneti · 2023 to 2026
$1.8MNCI NIH HHS F32 CA260735NCI NIH HHS K08 CA234416NCI NIH HHS K99 CA300923NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA269022NCI NIH HHS R01 CA251872NCI NIH HHS R01 CA261926NCI NIH HHS R01 CA271369NCI NIH HHS R37 CA258346NCI NIH HHS U54 CA283114NIDDK NIH HHS U2C DK135066NIGMS NIH HHS R35 GM143127NINDS NIH HHS K08 NS128271NINDS NIH HHS R01 NS110572NINDS NIH HHS R01 NS127799NINDS NIH HHS R01 NS129123
Abstract
The brain avidly consumes glucose to fuel neurophysiology
Indexed as
Brain NeoplasmsCerebral CortexGlioblastomaGlucoseAmino AcidsAnimalsCarbonCarbon IsotopesCell ProliferationCitric Acid CycleFemaleGliomaHumansMaleMiceNeurotransmitter AgentsAmino AcidsCarbonCarbon-13Carbon IsotopesGlucoseNeurotransmitter Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.