Evidence map›Paper›PMID 40903535›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

Prognostic impact of excessive mitochondrial fission in patients with heart failure and evaluation of mitochondrial dynamics-related miRNAs in heart failure.

Akihiro Shirakabe, Yoshiyuki Ikeda, Yoshihiro Uchikado, Masato Matsushita, Tomofumi Sawatani, Shota Shigihara, Kenichi Tani, Masaki Morooka, Masahito Takahashi, Nobuaki Kobayashi and 3 more

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Akihiro ShirakabeDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan. s6042@nms.ac.jp.
Yoshiyuki IkedaDepartment of Cardiovascular Medicine, National Hospital Organization, Minami Kyushu Hospital, Kagoshima, Japan.
Yoshihiro UchikadoDepartment of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
Masato MatsushitaDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Tomofumi SawataniDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Shota ShigiharaDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Kenichi TaniDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Masaki MorookaDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Masahito TakahashiDivision of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Nobuaki KobayashiCardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
Mitsuru OhishiDepartment of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
Junichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, USA.
Kuniya AsaiDepartment of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria are dynamic organelles that can change their morphology. The role of these mitochondrial dynamics in cardiomyocytes remains obscure in patients with heart failure (HF). Endomyocardial biopsies were performed consecutively in 127 HF patients, and mitochondrial morphology data were obtained from 111 patients by electron microscopy. The patients were divided into three groups according to mitochondrial area quartiles (fission [Q1, area ≤ 0.119 μm

Indexed as

Heart FailureMicroRNAsMitochondria, HeartMitochondrial DynamicsAgedFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPrognosisMicroRNAsNatriuretic Peptide, BrainPeptide Fragmentsheart failureimplemental hypertensionmiRNAmitochondrial dynamicsmortality

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.