Evidence map›Paper›PMID 40903523›Full record

ReviewNature reviews. Clinical oncology2025

Radiomics Quality Score 2.0: towards radiomics readiness levels and clinical translation for personalized medicine.

Philippe Lambin, Henry C Woodruff, Shruti Atul Mali, Xian Zhong, Sheng Kuang, Elizaveta Lavrova, Hamza Khan, Karim Lekadir, Alex Zwanenburg, Joseph Deasy and 8 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Clinical target volume radiomics from planning CT for pretreatment response prediction  in rectal cancer undergoing chemoradiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  11. Article
  12. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Philippe LambinThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands. philippe.lambin@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0001-7961-0191
Henry C WoodruffThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.ORCID http://orcid.org/0000-0001-7911-5123
Shruti Atul MaliThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
Xian ZhongThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
Sheng KuangThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
Elizaveta LavrovaThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.ORCID http://orcid.org/0000-0003-2751-790X
Hamza KhanThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
Karim LekadirDepartament de Matemàtiques i Informàtica, Universitat de Barcelona, Barcelona, Spain.
Alex ZwanenburgOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.ORCID http://orcid.org/0000-0002-0342-9545
Joseph DeasyDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maciej Bobowicz2nd Division of Radiology, Medical University of Gdansk, Gdansk, Poland.
Luis Marti-BonmatiLa Fe Health Research Institute, Biomedical Imaging Research Group and Imaging La Fe node, Distributed Network for Biomedical Imaging Unique Scientific and Technical Infra-structures, Valencia, Spain.ORCID http://orcid.org/0000-0002-8234-010X
Andrew MaidmentDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Michel DumontierDepartment of Advanced Computing Sciences, Institute of Data Science, Maastricht University, Maastricht, Netherlands.
Paul E KinahanDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
J Martijn NobelDepartment of Radiology and Nuclear Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, Netherlands.ORCID http://orcid.org/0000-0003-3379-7290
Sina AmirrajabThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
Zohaib SalahuddinThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.ORCID http://orcid.org/0000-0002-9900-329X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiomics is a tool for medical imaging analysis that could have a relevant role in precision oncology by offering precise quantitative support for clinical decision-making. The Radiomics Quality Score (RQS) is a tool developed to assess the rigour of radiomics studies that has now been widely adopted by researchers. Although RQS version 1.0 established a benchmark, an updated framework is required to account for evolving knowledge and ensure optimal evaluation of the quality of radiomics studies through the inclusion of fairness, explainability, rigorous quality control and harmonization. In this Review, we introduce the updated RQS 2.0, which maintains the scientific rigour of its predecessor and addresses these contemporary needs, and therefore could potentially accelerate clinical translation. Moreover, we introduce the radiomics readiness levels, inspired by the technology readiness level framework, which are integrated in RQS 2.0 and reflect nine distinct levels of incremental improvement in radiomics research with the ultimate aim of clinical implementation. We also detail anticipated future directions in radiomics, outlining a strategic vision to advance precision oncology, which is the ultimate aim of RQS 2.0.

Indexed as

Diagnostic ImagingNeoplasmsPrecision MedicineTranslational Research, BiomedicalHumansQuality ControlRadiomics

Identifiers

PMID40903523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.