Evidence map›Paper›PMID 40903493›Full record

ArticleBJC reports2025

Blood Clock Correlation Distance (BloodCCD) as a novel marker to detect circadian rhythm disruption in cancer survivors with insomnia.

Brian J Altman, Po-Ju Lin, Lindsey J Mattick, Elliot H Outland, Javier Bautista, Chin-Shang Li, Umang Gada, Kristina M Morris, Amelia M Knudsen-Clark, Daniel Mwangi and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJC reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02613364 (A Randomized Clinical Trial Comparing the Effectiveness of Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy for Treating Insomnia in Cancer Survivors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02613364 nacompletednot on this map

A Randomized Clinical Trial Comparing the Effectiveness of Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy for Treating Insomnia in Cancer Survivors

TypeinterventionalSponsorUniversity of Rochester NCORP Research BaseRan2016 to 2020Enrolled746ConditionsCancer Survivor, Insomnia, Malignant NeoplasmArmsBehavioral Intervention, Cognitive Intervention, Educational Intervention, Laboratory Biomarker Analysis, Monitoring Device
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Brian J AltmanDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. Brian_Altman@URMC.rochester.edu.ORCID http://orcid.org/0000-0002-3954-4916
Po-Ju LinWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
Lindsey J MattickDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Elliot H OutlandDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Javier BautistaDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Chin-Shang LiDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Umang GadaDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Kristina M MorrisDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Amelia M Knudsen-ClarkDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, USA.
Daniel MwangiDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Rachel E DeRolloDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Amber S KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Ian R KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Nikesha J GilmoreWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
Benjamin T EsparazHeartland NCORP, Cancer Care Specialists of Illinois, Decatur, IL, USA.
Amarinthia CurtisUpstate Carolina Consortium Community Oncology Research Program (UPSTATE), Greer, SC, USA.
Alison ConlinPacific Cancer Research Consortium (PCRC), Seattle, WA, USA.
Gianni MonacoInstitute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, 79106, Germany.
Jacob J HugheyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Karen M MustianWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
University of Rochester Wilmot Cancer Institute Support GrantP30CA272302 · NCI · UNIVERSITY OF ROCHESTER · PI John Ashton · 2025 to 2026
$6.4M
Yoga Versus CBT-I for Insomnia in Cancer Survivors and Biobehavioral MechanismsR01CA181064 · NCI · UNIVERSITY OF ROCHESTER · PI MUSTIAN, KAREN M. · 2014 to 2019
$3.1M
Clinical and Translational Cancer Control Research Training ProgramT32CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, Gary R Morrow · 2019 to 2026
$2.7M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
NCI NIH HHS K07 CA221931NCI NIH HHS P30 CA272302NCI NIH HHS R01 CA181064NCI NIH HHS T32 CA102618NCI NIH HHS UG1 CA189961NCI NIH HHS UG1CA189961NCI NIH HHS UG1CA189961-07S1
6 · The paper itself

Abstract

backgroundInsomnia is a toxicity of cancer and treatment for survivors without an objective biochemical measure. Circadian rhythms are 24-h cycles that influence physiologic processes including sleep, and disrupted rhythms may contribute to insomnia. Here, we use BloodCCD to assess circadian rhythms from RNA-sequencing of blood from cancer survivors with insomnia from the YOCAS-II trial. YOCAS-II aimed to determine whether YOCAS©® yoga or cognitive behavioral therapy for insomnia (CBT-I) improved insomnia in survivors compared with a behavioral placebo. We hypothesized that circadian rhythms are disrupted in survivors, and that insomnia severity correlates with the degree of circadian disruption.

methodsBloodCCD was developed to biochemically assess circadian rhythms in blood. It was adapted from the previously published Clock Correlation Distance (CCD) and uses a correlation matrix of 42 genes known to oscillate throughout the day in blood.

resultsCancer survivors had higher (worse) BloodCCD scores, indicating disrupted circadian clock, compared to healthy individuals. Furthermore, insomnia severity correlated with worse BloodCCD, and those in the YOCAS and behavioral placebo arm showed significant correlation between BloodCCD score and insomnia.

conclusionsBloodCCD shows promise as a biomarker to biochemically detect disrupted circadian rhythms in cancer survivors, and as an indicator for insomnia severity. CLINICAL TRIAL IDENTIFIER: NCT02613364.

Identifiers

PMID40903493
PMCPMC12408818

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.