ArticlePhytotherapy research : PTR2025
In Vivo Wound-Healing and Molecular Docking Studies Support the Traditional Use of Arisarum vulgare Aqueous Extract.
Article in Phytotherapy research : PTR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Molecular and Pharmacokinetic Rationale for the Use ofMolecules (Basel, Switzerland) · 2026Article
- Wound-Healing Efficacy ofFood science & nutrition · 2026Article
- In Vivo Wound-Healing and Molecular Docking Studies Support the Traditional Use of Arisarum vulgare Aqueous Extract.Phytotherapy research : PTR · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Algerian traditional medicine, Arisarum vulgare O. Targ. Tozz. (Araceae), locally known as "Elbgouga," is widely used to treat eczema, wounds, and burns. The aim of this study was to investigate, for the first time and by using in vivo and in silico molecular docking techniques, the possible effects of A. vulgare ultrasound-assisted aqueous extract (AVAE) on wound healing. The phytochemical profile was elucidated by LC-ESI-MS/MS analysis. Wistar albino rats were used to evaluate the AVAE ointment's acute cutaneous toxicity and wound-healing potential (1%, 2%, and 5% AVAEO). Through in silico investigations, TNF-α, IL-1β, MMP-9, TGF-β, VEGF, and EGFR were examined as possible therapeutic targets. Twenty-seven phytochemicals, belonging mainly to the flavonoids and phenolic acids' class, were identified and semi-quantified. The 5% AVAEO-treated group showed a significantly greater (p < 0.001) wound contraction (8-20 days) with respect to untreated and petroleum jelly groups, whereas no statistically significant difference was observed with respect to the Madecassol-treated group. On the contrary, the two lower doses (1% and 2% AVAEO) showed no statistically significant effects. Docking studies showed that A. vulgare bioactive compounds may have therapeutic effects on wound healing by targeting with high affinity TNFα, IL-1β, MMP-9, TGF-βR1, VEGF, and EGFR, counteracting inflammation, angiogenesis, and oxidative unbalance, and promoting wound repair. This study demonstrated that AVAE possesses in vivo wound healing properties and no dermal toxicity, shedding light also on the potential therapeutic targets involved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.