Evidence map›Paper›PMID 40903365›Full record

ArticleTrends in cell biology2025

Understanding human embryogenesis by building programmable stem cell-based models.

Carly Guiltinan, Gerrald A Lodewijk, Sayaka Kozuki, S Ali Shariati

Abstract read
In one paragraph

Article in Trends in cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carly GuiltinanDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA; Institute for the Biology of Stem Cells, University of California Santa Cruz, Santa Cruz, CA, USA.
Gerrald A LodewijkDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA; Institute for the Biology of Stem Cells, University of California Santa Cruz, Santa Cruz, CA, USA.
Sayaka KozukiDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA; Institute for the Biology of Stem Cells, University of California Santa Cruz, Santa Cruz, CA, USA.
S Ali ShariatiDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA; Institute for the Biology of Stem Cells, University of California Santa Cruz, Santa Cruz, CA, USA. Electronic address: alish@ucsc.edu.

Funding

Molecular feedback between cell division cycle and differentiation in pluripotent stem cellsR35GM147395 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Ali Shariati · 2022 to 2026
$1.9M
Determining feedback mechanisms between cell cycle and cell fate in pluripotent cellsR00GM126027 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SHARIATI, ALI · 2020 to 2022
$747k
NIGMS NIH HHS R00 GM126027NIGMS NIH HHS R35 GM147395
6 · The paper itself

Abstract

Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.

Indexed as

Embryonic DevelopmentModels, BiologicalStem CellsAnimalsHumansMiceCRISPR activationembryo modelsepigenome editingstem cells

Identifiers

PMID40903365
PMCPMC13299303

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.