SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2025
Effectiveness and safety of home-based
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Safety of exercise after pulmonary endarterectomy: a systematic review.ERJ open research · 2026Article
- Factors Influencing Physical Activity Engagement Amongst Those Living With Pulmonary Hypertension in the UK.Pulmonary circulation · 2026Article
- Clinical research on pulmonary hypertension from a 2025 perspective: a narrative review.Journal of thoracic disease · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPulmonary hypertension is a pathophysiological disorder with poor prognosis. Exercise intolerance and lower physical activity levels are common features of pulmonary hypertension and affect patients' quality of life. Exercise training effectively improves clinical outcomes in this population, but access to rehabilitation centres is often limited. A home-based exercise training component could be an accessible and cost-effective alternative, but the efficacy and safety of this approach in pulmonary hypertension remain unclear.
methodsWe conducted a systematic review and meta-analysis of studies retrieved from six international databases. The studies evaluated home-based exercise interventions in patients with pulmonary hypertension, including both stand-alone and hybrid setups, and assessed safety, efficacy (exercise capacity, cardiorespiratory outcomes and functional class) and adherence.
resultsWe included 19 studies. Compared with inactive controls, home-based exercise training improved the 6-min walk distance (mean difference (MD) 54.85 m, p<0.01), peak oxygen uptake (standardised MD 0.83 mL·kg
conclusionHome-based exercise interventions appear to be viable alternatives to centre-based programmes for patients with pulmonary hypertension, showing comparable improvements in clinical outcomes. However, limited reporting on self-monitoring may affect the overall safety assessment. Further research is needed to determine the optimal implementation of these interventions.
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Registered trials
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