Evidence map›Paper›PMID 40903047›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2025

Ambient air pollution exposure, mediating biomarkers and risk of COPD: a cohort study and meta-analysis.

Tinggui Wang, Mengdan Liang, Xiaoying Ye, Xiaoxiao Huang, Hanbing Chen, Xiongkun He, Mengying Xie, Xiaowei Xie, Xiannuan Jiang, Zhehui Chen and 3 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Air pollution-induced airway epithelial barrier dysfunction in COPD: a narrative review of mechanisms and therapeutic implications.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tinggui WangDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Mengdan LiangDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Xiaoying YeDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Xiaoxiao HuangDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Hanbing ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Xiongkun HeDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Mengying XieThe Second Clinical Medical School, Nanchang University, Nanchang, China.
Xiaowei XieDepartment of Urology, Harbin Medical University Cancer Hospital, Harbin, China.
Xiannuan JiangDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Zhehui ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Baosong XieDepartment of Respiratory and Critical Care Medicine, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, China.
Yiming ZengDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Center of Respiratory Medicine of Fujian Province, Quanzhou, China.
Xiaoxu XieDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China xxx@fjmu.edu.cn.ORCID https://orcid.org/0000-0002-3103-3724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited evidence exists on air pollution's systemic impact on lung function and mediating biomarkers. This study comprehensively evaluated associations between air pollution, COPD and lung function, while exploring biomarker mediation.

methodsA prospective analysis of 451 566 UK Biobank participants was conducted. Land use regression models estimated exposure to particulate matter (PM) ≤2.5 μm (PM

resultsElevated PM

conclusionAir pollution associates with lung function decline and elevated COPD risk, with White populations disproportionately affected. Lipid, inflammatory and haematological biomarkers mediate this relationship. Findings underscore the urgency of air pollution control to mitigate respiratory harm and inform targeted preventive and therapeutic strategies.

Indexed as

Air PollutantsAir PollutionInhalation ExposureLungParticulate MatterPulmonary Disease, Chronic ObstructiveAgedBiomarkersFemaleForced Expiratory VolumeHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentAir PollutantsBiomarkersParticulate Matter

Identifiers

PMID40903047
PMCPMC12406020

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.