Evidence map›Paper›PMID 40902895›Full record

ArticleJournal of advanced research2026

Genetic modifications boost chrexanthomycin yield and neuroprotective potential.

Wei Ye, Wenkang Ye, Xin Huang, Jingwen Wang, Weiyi She, Duli Huang, Xin Liu, Junjie Li, Dapeng Qin, Sin Yu Chik and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wei YeSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China; Key Laboratory of Functional Yeast of China National Light Industry, Hubei Key Laboratory of Natural Products Research and Development, Hubei Engineering Research Center for Bioenzyme Engineering Technology, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.
Wenkang YeSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Xin HuangSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Jingwen WangFood Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China.
Weiyi SheSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Duli HuangSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Xin LiuSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Junjie LiSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Dapeng QinSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Sin Yu ChikSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Bowen PanSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Weimin ZhangState Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Taomei LiuState Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Herman H-Y SungDepartment of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Baojun XuFood Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China.
Ian D WilliamsDepartment of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China.
Aifang ChengDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao Special Administrative Region, 999078, China; Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macao Special Administrative Region, 999078, China. Electronic address: chengaf@um.edu.mo.
Peiyuan QianSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China. Electronic address: boqianpy@ust.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChrexanthomycins, a unique class of pentangular polyphenols (PPs) conjugated with glucuronic acid, have demonstrated remarkable neuroprotective properties both in vitro and in vivo. However, their low yield has restricted their potential applications.

objectiveThis study aims to clarify the biosynthetic pathway and neuroprotective potency of chrexanthomycins, enhance their large-scale production potential, and discover novel derivatives with improved activities.

methodMultiple strategies were adopted, such as the heterologous expression of the chr gene cluster, knockout of negative regulators, overexpression of positive regulators, in vitro biochemical reactions, and deletion of tailoring enzymes to clarify the biosynthetic routine of chrexanthomycins. Caenorhabditis elegans was used to evaluate the neuroprotective potential of chrexanthomycins.

resultsThrough these approaches, we successfully elucidated the biosynthetic pathway of chrexanthomycins and significantly improved their yields by more than 10-fold in recombinant Streptomyces chrestomyceticus. Additionally, we explored the functions of hydratase ChrN and UDP-glucuronosyltransferase UGT50 in the biosynthesis of chrexanthomycins. Our efforts led to identifying a new derivative, chrexanthomycin G, which exhibited outstanding neuroprotective activities. This novel compound alleviates amyloid-β (Aβ) - induced oxidative stress, inhibits Aβ aggregation, and improves memory in C. elegans through chemotaxis tests.

conclusionsThese findings offer valuable insights into the complex mechanisms of the biosynthesis and biological activities of chrexanthomycins, laying a foundation for their potential application in treating neurodegenerative disorders.

Indexed as

Neuroprotective AgentsAmyloid beta-PeptidesAnimalsBiosynthetic PathwaysCaenorhabditis elegansOxidative StressStreptomycesAmyloid beta-PeptidesNeuroprotective AgentsBiosynthetic logicChrexanthomycinGenetic modificationMetabolic engineeringNeuroprotective activity

Identifiers

PMID40902895
PMCPMC13227249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.