Evidence map›Paper›PMID 40902696›Full record

ArticleAnalytical biochemistry2026

Continuous assay for the dNTP triphosphohydrolase of activated SAMHD1.

Roozbeh Eskandari, Daniel P Groom, Ryo Tamura, Vern L Schramm

Abstract read
In one paragraph

Article in Analytical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roozbeh EskandariDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, United States.
Daniel P GroomDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, United States.
Ryo TamuraDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, United States.
Vern L SchrammDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, United States. Electronic address: vern.schramm@einsteinmed.edu.

Funding

Targeting the PNP - SAMHD1 synthetic-lethal combination in cancerR01CA290537 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Vern L. Schramm · 2024 to 2026
$1.8M
NCI NIH HHS R01 CA290537
6 · The paper itself

Abstract

Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is the only member of the triphosphoric monoester hydrolase family in humans (dNTP + H

Indexed as

Enzyme AssaysSAM Domain and HD Domain-Containing Protein 1HumansKineticsPhosphoric Monoester HydrolasesPhosphoric Monoester HydrolasesSAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, human7-Methyl-6-thioguanosine (MESG)Coupled enzyme assaysPhosphate detectionT-cell leukemiaViral restriction

Identifiers

PMID40902696
PMCPMC12486158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.