ArticleCell host & microbe2025
A prophage intercepts pathogenic activity of infecting phage for defense.
Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The role of phages in plant-associated microbial communities.Essays in biochemistry · 2026Review
- Sequential receptor engagement dictates the broad host range and fitness trade-offs ofMicrobiology spectrum · 2026Article
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Authors and funding
2 authors.
Funding
Abstract
Bacteria counter bacteriophage threats using diverse anti-phage systems often encoded on prophages within hotspots for accessory genes. These prophages must ensure that encoded defense systems do not inhibit their spread. Here, we discover two anti-phage defense elements, RemS and PokE, encoded within the Gifsy-3 prophage of Salmonella enterica Typhimurium 14028 that restrict phage infection without affecting the lytic cycle of Gifsy-3. RemS, an ATPase, is expressed from a hotspot for accessory genes in lambdoid phages. PokE is a small membrane-depolarizing protein/peptide encoded within the Gifsy-3 lysis cassette. During infection by phage BTP1, pokE transcription is specifically driven by the Q antiterminator of BTP1, as the infecting phage prepares to express its lysis genes. PokE then disrupts the BTP1 lytic cycle through abortive infection. Altogether, this work uncovers how a prophage repurposes an essential feature of phage lytic cycles to both detect and respond to a phage-specific essential pathogenic activity.
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