Evidence map›Paper›PMID 40902519›Full record

ArticlePsychoneuroendocrinology2025

Personality and epigenetic aging: A multi-cohort and multi-clock study.

Yannick Stephan, Angelina R Sutin, Martina Luchetti, Antonio Terracciano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yannick StephanEuromov, University of Montpellier, France. Electronic address: yannick.stephan@umontpellier.fr.
Angelina R SutinDepartment of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, USA.
Martina LuchettiDepartment of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, USA.
Antonio TerraccianoDepartment of Geriatrics, College of Medicine, Florida State University, USA.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER L COE · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9M
Prenatal and Early Life Antecedents of Personality: An Intergenerational Lifespan ApproachR01AG053297 · NIA · FLORIDA STATE UNIVERSITY · PI Angelina R Sutin · 2017 to 2026
$4.3M
Personality and Dementia: Mechanisms and TrajectoriesR01AG068093 · NIA · FLORIDA STATE UNIVERSITY · PI TERRACCIANO, ANTONIO · 2020 to 2024
$3.0M
NCATS NIH HHS UL1 TR000427NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR023942NIA NIH HHS P01 AG020166NIA NIH HHS R01 AG053297NIA NIH HHS R01 AG068093NIA NIH HHS U01 AG009740NIA NIH HHS U19 AG051426
6 · The paper itself

Abstract

Epigenetic clocks are measures of biological aging related to critical health outcomes, including mortality. The present study examined whether personality traits are related to epigenetic aging. Participants (Age range: 17-98 years, N > 6000) were from the Health and Retirement Study, the Midlife in the United States study, and the UK Household Longitudinal Study. Measures of personality traits, demographic factors, first-generation (Hannum, Horvath), second-generation (PhenoAge, GrimAge), and third-generation (DunedinPoAM38/DunedinPace) epigenetic clocks were obtained in each sample. The strongest evidence emerged for conscientiousness: The meta-analysis indicated that higher conscientiousness was associated with a slower epigenetic aging as indexed by second- and third-generation clocks. The other traits were not consistently associated with the five clocks. Surprisingly, moderation by age indicated agreeableness was associated with slower epigenetic aging among relatively older but not younger adults. The present study suggests that conscientiousness is associated with slower epigenetic aging, particularly second and third-generation clocks trained on health-related outcomes.

Indexed as

AgingEpigenesis, GeneticPersonalityAdolescentAdultAgedAged, 80 and overCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedUnited KingdomUnited StatesYoung AdultAgingEpigenetic clocksPersonality

Identifiers

PMID40902519
PMCPMC13587623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.