ReviewCurrent opinion in immunology2025
Human inborn errors of type I interferon-independent intrinsic immunity in nonleukocytic cells.
Shen-Ying Zhang, Jean-Laurent Casanova, András N Spaan
Abstract readReview
In one paragraphReview in Current opinion in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
3 authors.
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; Paris Cité University, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA. Electronic address: shzh289@rockefeller.edu.
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; Paris Cité University, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France; Howard Hughes Medical Institute, The Rockefeller University, New York, USA.
András N SpaanDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: a.n.spaan@umcutrecht.nl.
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MStudy of the Cellular Basis of Herpes Simplex Encephalitis with hPSC-Derived CNS and PNS CellsR01NS072381 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$10.2MMonogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7MMolecular and cellular basis of epidermodysplasia verruciformisR01AI143810 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, JOUANGUY, EMMANUELLE · 2020 to 2024
$2.0MsnoRNA31 is critical for human cell-intrinsic immunity to HSV-1 in the central nervous systemR21AI151663 · NIAID · ROCKEFELLER UNIVERSITY · PI ZHANG, SHEN-YING · 2020 to 2021
$466kAutosomal dominant OTULIN deficiency and staphylococcal diseaseR21AI159728 · NIAID · ROCKEFELLER UNIVERSITY · PI BOISSON, BERTRAND, SPAAN, ANDRAS NIKO · 2022 to 2023
$466kHuman DBR1 defines a new pathway of intrinsic antiviral immunity in the CNSR21NS084255 · NINDS · ROCKEFELLER UNIVERSITY · PI ZHANG, SHEN-YING · 2013 to 2014
$464kNCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI143810NIAID NIH HHS R21 AI151663NIAID NIH HHS R21 AI159728NINDS NIH HHS R01 NS072381NINDS NIH HHS R21 NS084255
6 · The paper itselfAbstract
'Intrinsic immunity' is often used to refer to mechanisms of host defense operating in nonleukocytic cells. This term can refer to the intrinsic capacity of an individual cell to fend off invading microbes without help from other cells or of a group of similar cells to fend off invading microbes without help from other cell types. The intrinsic capacity of individual cells to defend themselves against invading microbes without assistance has received little attention and is the topic of this review. We also focus on nonleukocytic cells and on humans, the only species in which intrinsic immunity has been shown by genetic means to be essential for homeostasis in natural conditions at whole-body level. We review recent progress in our understanding of the type I interferon-independent intrinsic immunity of individual nonleukocytic cells, as inferred from human inborn errors of intrinsic immunity manifesting as infection or autoinflammation.
Indexed as
Immunity, InnateInterferon Type IAnimalsHumansInterferon Type I
Identifiers
PMID40902265
PMCPMC12529579
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390