Evidence map›Paper›PMID 40902195›Full record

ArticleChemMedChem2025

Synthesis of a Conformationally Fixed Bicyclomarin Derivative.

Jennifer Greve, Alexander F Kiefer, Uli Kazmaier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer GreveOrganic Chemistry, Saarland University, Campus C4.2, 66123, Saarbrücken, Germany.
Alexander F KieferHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany.ORCID https://orcid.org/0000-0002-4540-6501
Uli KazmaierOrganic Chemistry, Saarland University, Campus C4.2, 66123, Saarbrücken, Germany.ORCID https://orcid.org/0000-0001-9756-0589

Funding

Saarland University
6 · The paper itself

Abstract

Based on an X-ray structure of cyclomarin bound to ClpC1, a new conformationally fixed, bicyclic cyclomarin derivative is synthesized in an effort to enhance antituberculosis activity. The synthesis of the linear heptapeptide and the two macrolactamizations proceed smoothly. Only the very last synthetic step, the cleavage of a benzyl ether, provides a low yield. Despite the successful synthesis, the resulting bicyclic compound shows reduced activity compared to cyclomarin.

Indexed as

Heterocyclic Compounds, 2-RingPeptidesAntitubercular AgentsCrystallography, X-RayModels, MolecularMolecular ConformationMycobacterium tuberculosisOligopeptidesAntitubercular Agentscyclomarin AHeterocyclic Compounds, 2-RingOligopeptidesPeptidesclpC1cyclomarincyclopeptidesmacrolactamizationstuberculosis

Identifiers

PMID40902195
PMCPMC12597213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.