Evidence map›Paper›PMID 40901957›Full record

ArticleScience advances2025

Hybrid pneumatic-hydraulic actuation for MRI-guided robotic stereotactic neurointervention.

Shaoping Huang, Zhao He, Yi Chen, Jiafan Chen, Shijie Hong, Yi Zhang, Longyu Xu, Yixin Pan, Shuo Ma, Lian Xuan and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Shaoping HuangShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0000-0003-1509-0806
Zhao HeShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0000-0002-3988-2851
Yi ChenInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Jiafan ChenShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.
Shijie HongInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Yi ZhangInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0009-0002-3278-1705
Longyu XuDepartment of Neurosurgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0008-0598-8843
Yixin PanDepartment of Neurosurgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shuo MaDepartment of Neurosurgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0007-4582-2322
Lian XuanInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0009-0007-8815-3966
Qingdang MengShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.
Yong YangShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.
Yangyang XuShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.
Zecai LinShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.
Chuqian LouInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Cheng ZhouShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0009-0004-9143-947X
Weidong ChenShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0000-0001-8757-0679
Bomin SunDepartment of Neurosurgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Qingfang SunDepartment of Neurosurgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-2691-476X
Yuan FengShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0000-0003-1902-3408
Anzhu GaoShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0000-0001-8307-4416
Guang-Zhong YangShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.ORCID 0000-0003-4060-4020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic neurointervention is a common procedure for biopsy, injection, ablation, and implantation of electrodes for deep brain stimulation. Guided by preoperative imaging, conventional approaches are mostly performed manually, lacking operation stability and interactive feedback. The intraoperative magnetic resonance imaging (MRI) guidance enables both structural and functional assessment during operation, permitting interactive adaptation to tissue deformation and avoidance of critical anatomical regions. Here, we report an MRI-guided robotic system for stereotactic neurointervention. A macro-micro hybrid pneumatic-hydraulic actuated stereotactic robot with a large range of motion and high precision is developed. This is coupled with a compact bioinspired soft actuator for target intervention. A global-focal MRI sequence is proposed for interactive navigation, closed-loop control, and precise targeting. Validation is performed with phantom, cadaveric, and in vivo animal studies, showing positional accuracies of 0.39, 0.68, and 0.14 millimeters, respectively, demonstrating superior performance compared to the current state of the art in robotic-assisted stereotactic neurointervention.

Indexed as

Magnetic Resonance ImagingRoboticsRobotic Surgical ProceduresStereotaxic TechniquesAnimalsHumansPhantoms, ImagingSurgery, Computer-Assisted

Identifiers

PMID40901957
PMCPMC12407083

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.