Evidence map›Paper›PMID 40901885›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Loss of the ESX-5 secretion locus in

Benjamin Koleske, Saranathan Rajagopalan, Courtney Schill, Shichun Lun, Catherine Vilchèze, Lahari Das, Manish Gupta, Yazmin B Martinez-Martinez, William R Bishai, William R Jacobs

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. ThemBio · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin Koleske *Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-1479-218X
Saranathan Rajagopalan *Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Courtney SchillCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Shichun LunCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Catherine VilchèzeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Lahari DasDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Manish GuptaCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Yazmin B Martinez-MartinezCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-8734-4118
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-3321-3080

Funding

MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosisR24AI134650 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shazia Hamid, WILLIAM Robert JACOBS · 2017 to 2026
$5.6M
Glutamine metabolism inhibitors for TB and TB-HIV: dual action as host-directed therapies with antibacterial activityR01AI155602 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2020 to 2024
$4.0M
Targeted cell-depleting immunotherapy for TB and HIVR01AI152688 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2020 to 2024
$3.4M
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIVR37AI167750 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WILLIAM Ramses BISHAI, SABRA L. KLEIN · 2022 to 2026
$3.3M
Esx5 secretome in TB and TB-HIV pathogenesis and immunityR01AI192152 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI WILLIAM Ramses BISHAI, WILLIAM Robert JACOBS · 2025 to 2026
$1.6M
HHS | NIH (NIH) 1R01AI192152HHS | NIH (NIH) R01AI026170HHS | NIH (NIH) R01AI152688HHS | NIH (NIH) R01AI155602HHS | NIH (NIH) R24AI134650HHS | NIH (NIH) R37AI167750NIAID NIH HHS R01 AI026170NIAID NIH HHS R01 AI152688NIAID NIH HHS R01 AI155602NIAID NIH HHS R01 AI192152NIAID NIH HHS R24 AI134650NIAID NIH HHS R37 AI167750
6 · The paper itself

Abstract

The ESX-5 secretion system, uniquely found in slow-growing mycobacteria, is predicted to secrete over 150 proteins across the inner membrane of

Indexed as

Antigens, BacterialBacterial ProteinsMycobacterium tuberculosisGene DeletionGene Expression Regulation, BacterialVirulenceVirulence FactorsAntigens, BacterialBacterial ProteinsESX-5 protein, Mycobacterium tuberculosisVirulence FactorsESX systemmycobacterial secretionmycomembranePE/PPE proteins

Identifiers

PMID40901885
PMCPMC12435201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.