Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Enkai Li *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Ruochen Zang *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Takahiro KawagishiDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Wei ZhangDivision of Endocrinology, Department of Medicine, Diabetes, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis 63110, MO.
Kruthika IyerDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612.
Gaopeng HouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Qiru ZengDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Rita M MeganckDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2799-3754
Susan R RossDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612.ORCID 0000-0002-3094-3769
Xin WangKey Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Xiong SuDepartment of Biochemistry and Biophysics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu, China.ORCID 0000-0001-8998-1826
Siyuan DingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-5338-260X
Funding
The role of TRIM2 and SIRPA in New World Arenavirus entryR01AI159290 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUSAN R ROSS · 2022 to 2026
$2.5M
Interferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral AntagonismR01AI150796 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2024
$2.0M
Development of novel multivalent mucosal vaccines for human norovirusesR01AI183671 · NIAID · OHIO STATE UNIVERSITY · PI PURNIMA DUBEY, Siyuan Ding · 2025 to 2026
$1.6M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI150796HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI159290NIAID NIH HHS R01 AI150796NIAID NIH HHS R01 AI159290NIAID NIH HHS R01 AI183671
6 · The paper itself
Abstract
Despite the clinical significance of many nonenveloped viruses, the molecular mechanisms of their internalization and membrane penetration are not well understood. Rotaviruses (RVs) are nonenveloped double-stranded RNA viruses and the leading cause of severe dehydrating diarrhea in infants and young children. We identified fatty acid 2-hydroxylase (encoded by
Indexed as
EndosomesMixed Function OxygenasesRotavirusRotavirus InfectionsVirus UncoatingAnimalsCalciumDiarrheaHumansMiceVirus InternalizationVirus ReplicationCalciumMixed Function OxygenasescalciumendosomeFA2Hrotavirusuncoating
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Fatty acid 2-hydroxylase facilitates rotavirus uncoating and endosomal escape. · full record | OpenQuestion