Evidence map›Paper›PMID 40901736›Full record

ArticleMolecular biology of the cell2025

Acyl-CoA-binding protein AcbdA is required for peroxisome hitchhiking on early endosomes in

Bellana E Driscoll, Madison B Fountain, Isabella N Gates, Reihane Abdollahi, Allison M Langley, Matthew B Owens, Jenna R Christensen, John Salogiannis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Bellana E DriscollDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Madison B FountainDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Isabella N GatesDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
Reihane AbdollahiDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Allison M LangleyDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Matthew B OwensCellular, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT 05405.
Jenna R ChristensenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
John SalogiannisDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0002-1988-7284

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Vermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7M
Increasing the Complexity of Microtubule-based transport: Cargo adaptors and Hitchhiking on Vesicles.R35GM150857 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOHN SALOGIANNIS · 2023 to 2026
$1.7M
Evolution of Cargo TransportR00GM140269 · NIGMS · NORTHWESTERN UNIVERSITY · PI Jenna Christensen · 2024 to 2026
$747k
NIAID NIH HHS T32 AI055402NIGMS NIH HHS R00 GM140269NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R35 GM150857
6 · The paper itself

Abstract

Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an organelle that directly recruit microtubule-based motors. An alternative mechanism called hitchhiking was recently discovered: some organelles move, not by recruiting the motors directly, but instead by using membrane contact sites (MCS) to attach to motor-driven vesicles and hitchhike along microtubules. Organelle hitchhiking is observed across fungi and animals. In filamentous fungi, nearly all peroxisomes move by hitchhiking on early endosomes (EE). In the fungus

Indexed as

Aspergillus nidulansDiazepam Binding InhibitorEndosomesFungal ProteinsPeroxisomesAcyl Coenzyme ABiological TransportCarrier ProteinsEndoplasmic ReticulumMembrane ProteinsMicrotubulesProtein TransportAcyl Coenzyme ACarrier ProteinsDiazepam Binding InhibitorFungal ProteinsMembrane Proteins

Identifiers

PMID40901736
PMCPMC12636676

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.