Observational studyWorld journal of gastroenterology2025
Age- and gender-specific dynamics and next-generation reference intervals for pepsinogen in northern China.
Observational study in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPepsinogen (PG) and the PG I/II ratio (PGR) are critical indicators for diagnosing
aimTo investigate age- and sex-specific dynamics of PG and establish next-generation RIs for adults and the elderly in northern China.
methodsAfter screening, 708 healthy individuals were included in this observational study. Serum PG was measured using chemiluminescence immunoassay. Age- and sex-related effects on PG were analyzed with a two-way analysis of variance. RI partitioning was determined by the standard deviation ratio (SDR). Traditional RIs were established using a non-parametric approach. Generalized Additive Models for Location, Scale, and Shape (GAMLSS) modeled age-related trends and continuous reference percentiles for PG I and PG II. Reference limit flagging rates for both RI types were compared.
resultsPG I and PG II levels were influenced by age (
conclusionThis study elucidates the age- and sex-specific dynamics of PG and, to our knowledge, is the first to establish next-generation RIs for PG, supporting more individualized interpretation in laboratory medicine.
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